Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name dieldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
152486 Verma SR, Gupta AK, Bansal SK, Dalela RC: In vitro disruption of ATP dependent active transport following treatment with aldrin and its epoxy analog dieldrin in a fresh water teleost, Labeo rohita. Toxicology. 1978 Oct;11(2):193-201.

Tissue homogenates of brain, gill, liver and kidney of Labeo rohita were subjected in vitro to the various concentrations as 5.00, 1.66, 0.55, 0.18 and 0.06 mu M of 2 organochlorine pesticides aldrin and dieldrin and the disruption of ATP dependent active transport (involving ATPase) was studied.
193(2,3,3,3) Details
1447481 Janik F, Wolf HU: The Ca (2+)-transport-ATPase of human erythrocytes as an in vitro toxicity test system--acute effects of some chlorinated compounds. J Appl Toxicol. 1992 Oct;12(5):351-8.

Investigations to determine the inhibitory activity on the Ca (2+)-transport-ATPase of human erythrocyte membranes were performed with various compounds of toxicological significance, mostly chlorinated and mainly used as biocides, such as phenol, 4-chlorophenol, 2,4-dichlorophenol, 2,6-dichlorophenol, 3,4-dichlorophenol, 2,3,4-trichlorophenol, 2,3,4,5-tetrachlorophenol, pentachlorophenol (PCP), captan, folpet, captafol, (+)-camphene, toxaphene, dichlorodiphenyltrichloroethane (DDT), lindane, endrin, dieldrin, alpha-endosulfan, beta-endosulfan, paraquat, diallate, 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T).
34(0,1,1,4) Details
2974087 Mehrotra BD, Ravichandra Reddy S, Desaiah D: Effect of subchronic dieldrin treatment on calmodulin-regulated Ca2+ pump activity in rat brain. J Toxicol Environ Health. 1988;25(4):461-9.

Dieldrin inhibited both CaM-dependent and -independent Ca2+-ATPase activity and the enzyme activity decreased to 36% (CaM-dependent)--and 18% (basal) respectively after 60 d of intoxication.
112(1,2,2,2) Details
6224843 Mehrotra BD, Bansal SK, Desaiah D: Comparative effects of structurally related cyclodiene pesticides on ATPases. J Appl Toxicol. 1982 Dec;2(6):278-83.

Comparative effects of aldrin, dieldrin, endrin, isodrin and telodrin, on different ATPase activities in beef heart mitochondrial and rat brain synaptosomal fractions were determined in vitro.
10(0,0,1,5) Details
7149987 Bandyopadhyay SK, Tiwari RK, Mitra A, Mukherjee B, Banerjee A, Chatterjee GC: Effects of L-ascorbic acid supplementation on dieldrin toxicity in rats. Arch Toxicol. 1982 Sep;50(3-4):227-32.

The activities of Mg2+-ATPase in liver and acetylcholinesterase in brain were decreased under toxic doses of dieldrin.
6(0,0,1,1) Details
6124057 Bandyopadhyay SK, Tiwari RK, Bhattacharyya A, Chatterjee GC: Effect of dieldrin on rat liver plasma membrane enzymes. Toxicol Lett. 1982 Apr;11(1-2):131-4.

Dieldrin, an organochlorine insecticide, when administered orally to male albino rats at a dose of 5 mg/kg body weight/day for 15 days inhibits the enzyme Mg2+ -ATPase and stimulates the activity of 5'-nucleotidase and NADH-dehydrogenase in liver plasma membrane.
82(1,1,1,2) Details
4279713 Wells MR, Phillips JB, Murphy GG: ATPase activity in tissues of the map turtle, Graptemys geographica following in vitro treatment with aldrin and dieldrin. Bull Environ Contam Toxicol. 1974 Jun;11(6):572-6.
6(0,0,1,1) Details
6223810 Kunz HW, Tennekes HA, Port RE, Schwartz M, Lorke D, Schaude G: Quantitative aspects of chemical carcinogenesis and tumor promotion in liver. Environ Health Perspect. 1983 Apr;50:113-22.


A strong quantitative correlation between carcinogen dose, the extent of ATPase deficient areas, and the subsequent appearance of tumors has now been established for a number of hepatocarcinogens.
2(0,0,0,2) Details