Protein Information

Name Rieske iron sulfur protein
Synonyms RIS 1; RIS1; RISP; Rieske iron sulfur protein; UQCRFS 1; UQCRFS1; Ubiquinol cytochrome C reductase iron sulfur subunit mitochondrial; Ubiquinol cytochrome C reductase rieske iron sulfur…

Compound Information

Name sulfur
CAS sulfur

Reference List

PubMed Abstract RScore(About this table)
19549324 Willett CS, Ladner JT: Investigations of fine-scale phylogeography in Tigriopus californicus reveal historical patterns of population divergence. BMC Evol Biol. 2009 Jun 23;9:139.


RESULTS: Sequence variation in both cytochrome b (CYTB, mtDNA) and the rieske iron-sulfur protein (RISP, nuclear) are examined at a fine scale within four different regions for populations of T. californicus.
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20026009 Kuznetsov AM, Zueva EM, Masliy AN, Krishtalik LI: Redox potential of the Rieske iron-sulfur protein quantum-chemical and electrostatic study. Biochim Biophys Acta. 2010 Mar;1797(3):347-59. Epub 2009 Dec 21.

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19348884 Millett F, Durham B: Chapter 5 Use of ruthenium photooxidation techniques to study electron transfer in the cytochrome bc1 complex. Methods Enzymol. 2009;456:95-109.

Electron transfer from the Rieske iron-sulfur center [2Fe2S] to cyt c (1) was detected with a rate constant of 6 x 10 (4) s (-1) in R. sphaeroides cyt bc (1) with this method.
This electron transfer step is rate-limited by the rotation of the Rieske iron-sulfur protein in a conformational gating mechanism.
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19562034 Arsham AM, Neufeld TP: A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. PLoS One. 2009 Jun 29;4(6):e6068.


Rieske iron-sulfur protein, Dynamin-related protein 1).
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20023300 Lhee S, Kolling DR, Nair SK, Dikanov SA, Crofts AR: Modifications of protein environment of the [2Fe-2S] cluster of the bc1 complex: effects on the biophysical properties of the rieske iron-sulfur protein and on the kinetics of the complex. J Biol Chem. 2010 Mar 19;285(12):9233-48. Epub 2009 Dec 20.

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19660431 Hughes LM, Covian R, Gribble GW, Trumpower BL: Probing binding determinants in center P of the cytochrome bc (1) complex using novel hydroxy-naphthoquinones. Biochim Biophys Acta. 2010 Jan;1797(1):38-43. Epub 2009 Aug 4.


It acts by inhibiting the cytochrome bc (1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket.
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19528227 Moiseeva O, Bourdeau V, Roux A, Deschenes-Simard X, Ferbeyre G: Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol. 2009 Aug;29(16):4495-507. Epub 2009 Jun 15.


In addition, direct interference with mitochondrial functions by inhibiting the expression of the Rieske iron sulfur protein of complex III or the use of pharmacological inhibitors of the electron transport chain and oxidative phosphorylation was sufficient to trigger senescence.
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19674969 Tsunoyama Y, Bernat G, Dyczmons NG, Schneider D, Rogner M: Multiple Rieske proteins enable short- and long-term light adaptation of Synechocystis sp. J Biol Chem. 2009 Oct 9;284(41):27875-83. Epub 2009 Aug 12.


In contrast to eukaryotes, most cyanobacteria contain several isoforms of the Rieske iron-sulfur protein, PetC, resulting in heterogeneity in the composition of the cytochrome b (6) f complexes.
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20025846 Berry EA, Huang LS, Lee DW, Daldal F, Nagai K, Minagawa N: Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex. Biochim Biophys Acta. 2010 Mar;1797(3):360-70. Epub 2009 Dec 16.


Indeed, the altered electron paramagnetic resonance (EPR) lineshape of the Rieske iron-sulfur protein, and the light-induced, time-resolved cytochrome b and c reduction kinetics of Rhodobacter capsulatus cytochrome bc (1) complex in the presence of ascochlorin demonstrated that this inhibitor can bind to both the Q (o) and Q (i) sites of the bacterial enzyme.
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20091229 Baymann F, Nitschke W: Heliobacterial Rieske/cytb complex. . Photosynth Res. 2010 Jan 21.


It is composed of a diheme cytochrome c, and a Rieske iron-sulfur protein, together with transmembrane cytochrome b (6) and subunit IV.
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