| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | carbaryl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3102203 | Knight EV, Chin BH, Ueng TH, Alvares AP: Differences in the in vivo and in vitro effects of the insecticide, carbaryl on rat hepatic monooxygenases. Drug Chem Toxicol. 1986;9(3-4):253-73. In vitro, carbaryl caused marked inhibition of ethylmorphine and benzphetamine N-demethylases, benzo (a) pyrene hydroxylase, 7-ethoxycoumarin and 7-ethoxyresorufin O-deethylase in liver microsomes. |
162(2,2,2,2) | Details |
| 6193957 | Mostafa MH, El-Bassiouni EA, El-Sewedy SM, Tawfic T, El-Sebae AH: Influence of pretreatment with various insecticides on the N-demethylation of dimethylnitrosamine. Environ Res. 1983 Oct;32(1):57-61. While pretreatment with carbaryl, a derivative, was without effect, moderate elevation in the activity of both demethylases was observed following administration of carbofuran. |
83(1,1,1,3) | Details |
| 6443788 | Chan HH, Buhler DR: Comparison of nitrosocarbaryl and carbaryl: in vitro effects on hepatic microsomal aryl hydrocarbon hydroxylase, aminopyrine N-demethylase, epoxide hydrolase and cytosolic glutathione-S-transferase. Proc Natl Sci Counc Repub China B. 1984 Oct;8(4):302-7. Nitrosocarbaryl was more potent and had much higher inhibitory effect than carbaryl on microsomal aryl hydrocarbon hydroxylase, aminopyrine N-demethylase, epoxide hydrolase and cytosolic glutathione-S-transferase. |
44(0,1,3,4) | Details |
| 2493170 | Beraud M, Forgue MF, Pipy B, Derache P: Interaction of carbaryl and N-nitrosocarbaryl with microsomal monooxygenase activities. Toxicol Lett. 1989 Feb;45(2-3):251-60. The inhibitory effect of the nitroso-compound is demonstrated to be non-competitive on aminopyrine N-demethylase, p-nitroanisole O-demethylase and hydroxylase. |
2(0,0,0,2) | Details |
| 8382714 | Gupta M, Amma MK: Alterations in hepatic biochemistry of mice intoxicated with MIC, carbaryl and thiram. J Appl Toxicol. 1993 Jan-Feb;13(1):33-7. The activities of drug-metabolizing enzymes (aminopyrine demethylase-- and -linked--and hydroxylase) were found to increase with all three compounds in general. |
1(0,0,0,1) | Details |
| 6156018 | Beraud M, Gaillard S, Derache R: Inhibition of two rat hepatic microsomal drug-metabolizing enzymes by a carcinogenic N-nitrosated pesticide: N-nitrosocarbaryl. Chem Biol Interact. 1980 Jul;31(1):103-12. The two following microsomal enzymatic activities were assayed: aromatic hydroxylase and p-nitroanisole O-demethylase; the levels of cytochrome P-450, proteins and RNA were measured in the hepatic microsomal fraction. |
1(0,0,0,1) | Details |
| 9858662 | Sandoz C, Lesca P, Carpy A, Laguionie M, Narbonne JF: Effects of carbaryl and naphthalene on rat hepatic CYP1A1/2: potential binding to Ah receptor and 4S benzo (a) pyrene-binding protein. Int J Mol Med. 1998 Nov;2(5):615-23. |
0(0,0,0,0) | Details |