Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name carbaryl
CAS

Reference List

PubMed Abstract RScore(About this table)
6790724 Tanaka R, Fujisawa S, Nakai K: Study on the absorption and protein binding of carbaryl, dieldrin and paraquat in rats fed on protein diet. J Toxicol Sci. 1981 Feb;6(1):1-11.

In serum, carbaryl was bound mainly to albumin and partly to globulins.
82(1,1,1,2) Details
9231337 Shrewsbury RP, Johnson LW, Oliver SR: Influence of moderate haemodilution with fluosol or normal saline on carbaryl disposition in Sprague-Dawley rats. J Pharm Pharmacol. 1997 Mar;49(3):236-40.

In rats carbaryl undergoes extensive biotransformation involving both albumin-mediated hydrolysis and cytochrome P-450-mediated metabolism; studies have suggested that approximately one-half of a carbaryl dose is hydrolysed and one-half is metabolized.
32(0,1,1,2) Details
15235763 Sogorb MA, Carrera V, Vilanova E: Hydrolysis of carbaryl by human serum albumin. . Arch Toxicol. 2004 Nov;78(11):629-34. Epub 2004 Jul 2.

The extrapolation of the hydrolysis rate to physiological albumin concentrations suggests that albumin might be playing a critical role in the detoxication of carbaryl.
6(0,0,1,1) Details
11952338 Sogorb MA, Carrera V, Benabent M, Vilanova E: Rabbit serum albumin hydrolyzes the carbamate carbaryl. . Chem Res Toxicol. 2002 Apr;15(4):520-6.

Human, chicken, and bovine serum albumins were also able to hydrolyze carbaryl.
6(0,0,1,1) Details
16944101 Sogorb MA, Alvarez-Escalante C, Carrera V, Vilanova E: An in vitro approach for demonstrating the critical role of serum albumin in the detoxication of the carbamate carbaryl at in vivo toxicologically relevant concentrations. Arch Toxicol. 2007 Feb;81(2):113-9. Epub 2006 Aug 31.

Although the efficacy of the enzymatic hydrolysis is low, the extrapolation of our results to the physiological albumin high concentrations (around 40 mg ml (-1)) suggests that the hydrolysis of carbaryl by serum albumins plays a critical role in the detoxication of this carbamate at in vivo toxicologically relevant concentrations.
6(0,0,1,1) Details
18996165 Eraslan G, Kanbur M, Silici S: Effect of carbaryl on some biochemical changes in rats: the ameliorative effect of bee pollen. Food Chem Toxicol. 2009 Jan;47(1):86-91. Epub 2008 Oct 21.

At the same time, levels/activities of total protein, albumin, glucose, triglyceride, T-cholesterol, T-bilirubin, BUN, creatinine, uric acid, GGT, LDH, AST, ALT and ALP, magnesium, sodium, potassium and chloride were evaluated in serum samples.
1(0,0,0,1) Details