Protein Information

Name serotonin receptor
Synonyms 5 hydroxytryptamine receptor 6; serotonin receptor; 5 HT 6; 5 HT6; 5 hydroxytryptamine (serotonin) receptor 6; 5 hydroxytryptamine 6 receptor; HTR 6; HTR6…

Compound Information

Name chlordecone
CAS

Reference List

PubMed Abstract RScore(About this table)
6203618 Gandolfi O, Cheney DL, Hong JS, Costa E: On the neurotoxicity of chlordecone: a role for gamma-aminobutyric acid and serotonin. Brain Res. 1984 Jun 11;303(1):117-23.

Since tremors elicited by chlordecone are attenuated by the administration of serotonin receptor blockers and since chlordecone increases serotonin (5-HT) turnover, we studied whether 5-HT recognition sites are modified following chlordecone administration.
31(0,1,1,1) Details
6200957 Hong JS, Tilson HA, Uphouse LL, Gerhart J, Wilson WE: Effects of chlordecone exposure on brain neurotransmitters: possible involvement of the serotonin system in chlordecone-elicited tremor. Toxicol Appl Pharmacol. 1984 Apr;73(2):336-44.

This study plus the previous finding that pizotifen (BC-105), a serotonin receptor blocker, attenuated chlordecone-elicited tremor strongly suggests a possible involvement of the serotonin system in mediating the tremor elicited by this insecticide.
6(0,0,1,1) Details