Protein Information

Name CD4
Synonyms CD4; CD4 antigen (p55); CD4 molecule; CD4mut; T cell antigen T4/LEU3; T cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; T cell surface glycoprotein CD4 precursor…

Compound Information

Name chlordecone
CAS

Reference List

PubMed Abstract RScore(About this table)
18951962 Wang F, Sobel ES, Butfiloski EJ, Roberts SM: Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW) F (1) mice. Toxicol Lett. 2008 Dec 15;183(1-3):1-9. Epub 2008 Sep 18.

On the other hand, both chlordecone and E2 increased Bcl-2 expression in CD4 T-cells and reduced CD4 T-cell apoptosis without affecting their proliferation.
81(1,1,1,1) Details
17996692 Wang F, Roberts SM, Butfiloski EJ, Sobel ES: Diminished prolactin from chlordecone treatment in ovariectomized (NZBxNZW) F (1) mice. Int Immunopharmacol. 2007 Dec 15;7(13):1808-12. Epub 2007 Sep 17.

Prolactin receptor in purified splenic B and CD4 T cells from treated animals, assessed through measurement of mRNA using quantitative real-time PCR, was increased by E2 treatment but unchanged in response to chlordecone.
6(0,0,1,1) Details