Protein Information

Name Met enkephalin
Synonyms Met enkephalin; enkephalin; M enkephalin

Compound Information

Name chlordecone
CAS

Reference List

PubMed Abstract RScore(About this table)
2581193 Hong JS, Hudson PM, Yoshikawa K, Ali SF, Mason GA: Effects of chlordecone administration on brain and pituitary peptide systems. Neurotoxicology. 1985 Spring;6(1):167-82.

Similarly, chlordecone treatment reduced the pituitary content of enkephalin in a manner identical to that of estrogen.
170(2,2,3,5) Details
6186955 Hong JS, Ali SF: Chlordecone (Kepone) exposure in the neonate selectively alters brain and pituitary endorphin levels in prepuberal and adult rats. Neurotoxicology. 1982 Oct;3(2):111-8.

These results suggest that hypothalamo-pituitary axis may be the primary neural target affected by chlordecone and estrogen-like activity may be related to the chlordecone-elicited decrease in pituitary [Met5]-enkephalin level.
38(0,1,2,3) Details
6204421 Hudson PM, Yoshikawa K, Ali SF, Lamb JC 4th, Reel JR, Hong JS: Estrogen-like activity of chlordecone (kepone) on the hypothalamo-pituitary axis: effects on the pituitary enkephalin system. Toxicol Appl Pharmacol. 1984 Jul;74(3):383-9.
18(0,0,3,3) Details
6186956 Ali SF, Hong JS, Wilson WE, Lamb JC, Moore JA, Mason GA, Bondy SC: Subchronic dietary exposure of rats to chlordecone (Kepone) modifies levels of hypothalamic beta-endorphin. Neurotoxicology. 1982 Oct;3(2):119-24.

These consisted of biogenic amines within the caudate nucleus, pituitary and hypothalamic met-enkephalin and circulating prolactin, growth hormone, and estrogen.
1(0,0,0,1) Details