| Name | progesterone receptor |
|---|---|
| Synonyms | NR3C3; PGR; PR; Progesterone receptor; Progesterone receptors |
| Name | chlordecone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 93289 | Hammond B, Katzenellenbogen BS, Krauthammer N, McConnell J: Estrogenic activity of the insecticide chlordecone (Kepone) and interaction with uterine estrogen receptors. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6641-5. When injected into immature rats, chlordecone translocates estrogen receptor sites to the uterine nucleus, increases uterine weight, and stimulates the synthesis of the progesterone receptor, an estrogen receptor-mediated process. |
82(1,1,1,2) | Details |
| 1725496 | Williams J, Uphouse L: Vaginal cyclicity, sexual receptivity, and eating behavior of the female rat following treatment with chlordecone. Reprod Toxicol. 1991;5(1):65-71. Chlordecone treatment on diestrus 2 reduced the number of progesterone receptors in uterine tissue of females on the predicted day of proestrus. |
81(1,1,1,1) | Details |
| 2476871 | Eckols K, Williams J, Uphouse L: Effects of chlordecone on progesterone receptors in immature and adult rats. Toxicol Appl Pharmacol. 1989 Sep 15;100(3):506-16. The ability of the chlorinated pesticide chlordecone to induce the CNS (hypothalamus and preoptic area) plus pituitary and uterine progesterone receptors was examined in CDF-344 female rats following treatment with 25 micrograms or with 75 mg/kg chlordecone. |
45(0,1,3,5) | Details |
| 9607801 | Das SK, Tan J, Johnson DC, Dey SK: Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary and xenoestrogen. Endocrinology. 1998 Jun;139(6):2905-15. To examine this further, we compared the effects of estrogenic (o,p'-DDT [1-(o-chlorophenyl)-1-(p-chlorophenyl) 2,2,2-trichloroethane] and Kepone, chlordecone) and nonestrogenic (p,p'-DDD [1,1-dichloro-2,2-bis (p-chlorophenyl) ethane], a metabolite of p,p'-DDT) xenobiotics with those of 17beta- (E2) and 4-hydroxyestradiol-17beta (4-OH-E2), a metabolite of E2, on uterine expression of lactoferrin (LF) and progesterone receptor (PR). |
32(0,1,1,2) | Details |
| 2423933 | Uphouse L, Eckols K, Sierra V, Kolodziej M, Brown H: Failure of chlordecone (Kepone) to induce behavioral estrus in adult ovariectomized rats. Neurotoxicology. 1986 Spring;7(1):127-41. Furthermore, chlordecone attenuated the increase in progesterone receptors seen after treatment. |
7(0,0,1,2) | Details |
| 14579009 | Scippo ML, Argiris C, Van De Weerdt C, Muller M, Willemsen P, Martial J, Maghuin-Rogister G: Recombinant human androgen and progesterone receptors for detection of potential endocrine disruptors. Anal Bioanal Chem. 2004 Feb;378(3):664-9. Epub 2003 Oct 25. The tested chemicals are organochlorine insecticides (DDT and its metabolites, methoxychlor, aldrin, dieldrin, chlordecone, lindane, trichlorobenzene), estrogenic insecticides (endosulfan, toxaphene, nonachlor), herbicides (alachlor and atrazine), fungicides (benomyl and vinclozolin), industrial chemicals (nonylphenol, bisphenol A, diphenylphtalate), antioxidants (butylated hydroxyanisol) and some phytoestrogens. |
2(0,0,0,2) | Details |
| 10774817 | Hodges LC, Bergerson JS, Hunter DS, Walker CL: Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro. Toxicol Sci. 2000 Apr;54(2):355-64. In addition, these compounds stimulated transcription of the vitellogenin -response element via the ER in a transcriptional reporter gene assay and induced the expression of an endogenous -responsive gene, the progesterone receptor (PR). |
1(0,0,0,1) | Details |
| 7524197 | Laws SC, Carey SA, Hart DW, Cooper RL: Lindane does not alter the estrogen receptor or the -dependent induction of progesterone receptors in sexually immature or ovariectomized adult rats. Toxicology. 1994 Sep 6;92(1-3):127-42. Chlordecone (kepone; 40 mg/kg; i.p.) was used in Study 2 as a positive control for the alteration of the -induction of PR in the pituitary. |
0(0,0,0,0) | Details |