Protein Information

Name ornithine decarboxylase
Synonyms ODC; ODC 1; ODC 2; ODC1; ODC1 protein; ODC2; ODCP; Ornithine decarboxylase…

Compound Information

Name chlordecone
CAS

Reference List

PubMed Abstract RScore(About this table)
1724372 Rotenberg SA, Weinstein IB: Two polychlorinated hydrocarbons cause phospholipid-dependent protein kinase C activation in vitro in the absence of calcium. Mol Carcinog. 1991;4(6):477-81.


Northern blot analysis of expression of TPA-inducible genes by kepone showed slight expression of phorbin and ornithine decarboxylase in murine embryo fibroblasts.
1(0,0,0,1) Details
1706540 Soni MG, Mehendale HM: Protection from chlordecone-amplified carbon tetrachloride toxicity by cyanidanol: regeneration studies. Toxicol Appl Pharmacol. 1991 Mar 15;108(1):58-66.

Favorably altered polyamine metabolism was evident from the stimulated ornithine decarboxylase, as well as from the stimulated interconversion of the higher polyamines to maintain increased concentration of putrescine.
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2475629 Rao SB, Young RA, Mehendale HM: Hepatic polyamines and related enzymes following chlordecone-potentiated carbon tetrachloride toxicity in rats. J Biochem Toxicol. 1989 Spring;4(1):55-63.

There was significant elevation in liver ornithine decarboxylase, S-adenosylmethionine decarboxylase, and putrescine at 24 hr and spermidine N1-acetyltransferase, N1-acetylputrescine, putreanine, putrescine, and N1-acetylspermidine at 6 hr in rats treated with the high dose of CCl4 alone compared to the combination treatment.
1(0,0,0,1) Details
2436115 Bondy SC, Hong JS: Modulation of adrenal ornithine decarboxylase by chlordecone, p,p'DDT and permethrin. Neurotoxicology. 1987 Spring;8(1):15-22.
87(1,1,2,2) Details
1698228 Rao SB, Young RA, Mehendale HM: Perturbations in polyamines and related enzymes following chlordecone-potentiated bromotrichloromethane hepatotoxicity. J Biochem Toxicol. 1990 Spring;5(1):23-32.

Hepatic levels of ornithine decarboxylase, S-adenosylmethionine decarboxylase, N1-acetylputrescine, N1-acetylspermidine, putrescine, spermidine, and spermine at the end of 24 hr increased after exposure to a low dose of BrCCl3 alone as compared to exposure to a high dose alone or the low-dose combination of CD and BrCCl3.
1(0,0,0,1) Details
2427159 Tilson HA, Emerich D, Bondy SC: Inhibition of ornithine decarboxylase alters neurological responsiveness to a tremorigen. Brain Res. 1986 Jul 30;379(1):147-50.

In contrast, the induction of tremor by chlordecone, a neurotoxic agent that affects neuronal ionic processes, is significantly attenuated by pretreatment with DFMO.
1(0,0,0,1) Details