Protein Information

Name calmodulin
Synonyms CALM; CAM; CALM 1; CALM 2; CALM 3; CALM1; CALM2; CALM3…

Compound Information

Name chlordecone
CAS

Reference List

PubMed Abstract RScore(About this table)
2416942 Desaiah D, Chetty CS, Rao KS: Chlordecone inhibition of calmodulin activated calcium ATPase in rat brain synaptosomes. J Toxicol Environ Health. 1985;16(2):189-95.
256(3,3,5,6) Details
1692334 Vig PJ, Desaiah D, Mehrotra BD: Chlordecone interaction of calmodulin binding with phosphodiesterase. . J Appl Toxicol. 1990 Feb;10(1):55-7.
87(1,1,2,2) Details
1704867 Kodavanti PR, Kodavanti UP, Mehendale HM: Carbon tetrachloride-induced alterations of hepatic calmodulin and free calcium levels in rats pretreated with chlordecone. Hepatology. 1991 Feb;13(2):230-8.
13(0,0,2,3) Details
1717700 Desaiah D, Pentyala SN, Trottman CH, Vig PJ, Sekhon BS: Combined effects of carbon tetrachloride and chlordecone on calmodulin activity in gerbil brain. J Toxicol Environ Health. 1991 Oct;34(2):219-28.
7(0,0,1,2) Details
2616064 Kodavanti PR, Mehrotra BD, Chetty SC, Desaiah D: Inhibition of calmodulin activated adenylate cyclase in rat brain by selected insecticides. Neurotoxicology. 1989 Summer;10(2):219-28.

Our earlier experiments indicated that plictran, chlordecone and other insecticides affect the calcium transport across cell membranes.
2(0,0,0,2) Details
1701552 Kodavanti PR, Cameron JA, Yallapragada PR, Desaiah D: Effect of chlordecone (Kepone) on calcium transport mechanisms in rat heart sarcoplasmic reticulum. Pharmacol Toxicol. 1990 Sep;67(3):227-34.

Cardiac SR Ca2 (+)-ATPase. 45Ca-uptake and cAMP as well as calmodulin (CaM) dependent protein phosphorylation were measured.
1(0,0,0,1) Details
10234476 Rao MR, Kanji VK, Sekhar V: Pesticide induced changes of nitric oxide synthase in rat brain in vitro. Drug Chem Toxicol. 1999 May;22(2):411-20.


We further demonstrated that these insecticides inhibit calmodulin (CaM)-stimulated NOS activity without affecting the basal enzyme activity.
1(0,0,0,1) Details
16413991 Li X, Zhang S, Safe S: Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds. J Steroid Biochem Mol Biol. 2006 Feb;98(2-3):122-32. Epub 2006 Jan 18.


17beta-Estradiol (E2) activates non-genomic pathways in MCF-7 cells, and this study investigates the effects of structurally-diverse estrogenic compounds on activation of mitogen-activated protein kinase (MAPK), phosphatidylinositol-3-kinase (PI3-K), protein kinase C (PKC), PKA, and calcium calmodulin-dependent kinase IV (CaMKIV).
1(0,0,0,1) Details
1693008 Vig PJ, Mehrotra BD, Desaiah D: Holothurin: an activator of bovine brain 3'-5' phosphodiesterase. . Res Commun Chem Pathol Pharmacol. 1990 Mar;67(3):419-22.

The effect of marine toxin, holothurin A, on calmodulin (CaM)-dependent bovine brain 3'-5' phosphodiesterase (PDE) was studied.
CaM antagonist W-7 and an organochlorine compound chlordecone significantly inhibited holothurin stimulated PDE.
1(0,0,0,1) Details