Protein Information

Name phosphodiesterase
Synonyms CAMP specific phosphodiesterase variant PDE4A 10; CAMP specific phosphodiesterase variant TM3; CAMP specific phosphodiesterase; Cyclic AMP phosphodiesterase PDE4A11; Cyclic AMP specific phosphodiesterase HSPDE4A10; DPDE 2; DPDE2; PDE 4…

Compound Information

Name chlordecone
CAS

Reference List

PubMed Abstract RScore(About this table)
1692334 Vig PJ, Desaiah D, Mehrotra BD: Chlordecone interaction of calmodulin binding with phosphodiesterase. . J Appl Toxicol. 1990 Feb;10(1):55-7.
32(0,1,1,2) Details
2845111 Kodavanti PR, Mehrotra BD, Chetty SC, Desaiah D: Effect of selected insecticides on rat brain synaptosomal adenylate cyclase and phosphodiesterase. J Toxicol Environ Health. 1988;25(2):207-15.

Previous reports from our laboratory and others clearly indicated that organochlorine insecticides such as chlordecone and DDT are potent inhibitors of ATPases involved in active ion transport.
4(0,0,0,4) Details
1693008 Vig PJ, Mehrotra BD, Desaiah D: Holothurin: an activator of bovine brain 3'-5' phosphodiesterase. . Res Commun Chem Pathol Pharmacol. 1990 Mar;67(3):419-22.

CaM antagonist W-7 and an organochlorine compound chlordecone significantly inhibited holothurin stimulated PDE.
2(0,0,0,2) Details