Protein Information

Name bcl 2
Synonyms Apoptosis regulator Bcl 2; B cell CLL/lymphoma 2; B cell lymphoma protein 2 alpha; B cell lymphoma protein 2 alpha isoform; BCL2; Bcl 2; B cell CLL/lymphoma 2s; B cell lymphoma protein 2 alphas…

Compound Information

Name chlordecone
CAS

Reference List

PubMed Abstract RScore(About this table)
18951962 Wang F, Sobel ES, Butfiloski EJ, Roberts SM: Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW) F (1) mice. Toxicol Lett. 2008 Dec 15;183(1-3):1-9. Epub 2008 Sep 18.

On the other hand, both chlordecone and E2 increased Bcl-2 expression in CD4 T-cells and reduced CD4 T-cell apoptosis without affecting their proliferation.
31(0,1,1,1) Details
17578864 Wang F, Roberts SM, Butfiloski EJ, Morel L, Sobel ES: Acceleration of autoimmunity by organochlorine pesticides: a comparison of splenic B-cell effects of chlordecone and estradiol in (NZBxNZW) F1 mice. Toxicol Sci. 2007 Sep;99(1):141-52. Epub 2007 Jun 19.

Both treatments increased B-cell bcl-2 and shp-1 gene expression and enhanced ICAM-1 and VCAM-1 protein levels in GC B cells.
1(0,0,0,1) Details