| Name | aldo keto reductase (protein family or complex) |
|---|---|
| Synonyms | aldo keto reductase; aldo keto reductases |
| Name | chlordecone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2420999 | Molowa DT, Wrighton SA, Blanke RV, Guzelian PS: Characterization of a unique aldo-keto reductase responsible for the reduction of chlordecone in the liver of the gerbil and man. J Toxicol Environ Health. 1986;17(4):375-84. |
83(1,1,1,3) | Details |
| 9310340 | Jez JM, Flynn TG, Penning TM: A new nomenclature for the aldo-keto reductase superfamily. Biochem Pharmacol. 1997 Sep 15;54(6):639-47. |
3(0,0,0,3) | Details |
| 2427522 | Molowa DT, Shayne AG, Guzelian PS: Purification and characterization of chlordecone reductase from human liver. J Biol Chem. 1986 Sep 25;261(27):12624-7. The toxic organochlorine pesticide, chlordecone (Kepone), is excreted in human bile primarily as a stable, reduced monoalcohol metabolite. We purified this enzyme from human liver and found that chlordecone reductase resembles the family of xenobiotic metabolizing enzymes referred to as the aldo-keto reductases based on its biochemical characteristics, including its ability to catalyze the reduction of a carbonyl-containing substrate. |
3(0,0,0,3) | Details |
| 10510318 | O'connor T, Ireland LS, Harrison DJ, Hayes JD: Major differences exist in the function and tissue-specific expression of human aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. Biochem J. 1999 Oct 15;343 Pt 2:487-504. |
2(0,0,0,2) | Details |
| 8446108 | Lacy WR, Washenick KJ, Cook RG, Dunbar BS: Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity. Mol Endocrinol. 1993 Jan;7(1):58-66. Amino acid sequence data indicate a similarity to human chlordecone reductase, bovine lung prostaglandin F synthase, human aldose reductase, human aldehyde reductase, and frog lens rho-crystallin, placing rabbit ovarian 20 alpha HSD in the aldo-keto reductase family of proteins. |
2(0,0,0,2) | Details |
| 2187532 | Winters CJ, Molowa DT, Guzelian PS: Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase. Biochemistry. 1990 Jan 30;29(4):1080-7. Chlordecone (Kepone), a toxic organochlorine pesticide, undergoes bioreduction to in human liver. This reaction is controlled by a cytosolic enzyme, chlordecone reductase (CDR), which may be of the aldo-keto reductase family of xenobiotic metabolizing enzymes [Molowa et al. (1986) J. |
1(0,0,0,1) | Details |
| 8172618 | Miura R, Shiota K, Noda K, Yagi S, Ogawa T, Takahashi M: Molecular cloning of cDNA for rat ovarian 20 alpha-hydroxysteroid dehydrogenase (HSD1). Biochem J. 1994 Apr 15;299 ( Pt 2):561-7. The sequence showed high similarity with those of rat liver 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD), bovine lung prostaglandin F synthase (PGFS), human liver chlordecone reductase (CDR), frog lens rho-crystallin and aldose reductases, indicating that 20 alpha-HSD belongs to the aldo-keto reductase family. |
1(0,0,0,1) | Details |
| 8274401 | Qin KN, New MI, Cheng KC: Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol. 1993 Dec;46(6):673-9. Because 3 alpha-hydroxysteroid dehydrogenase and human chlordecone reductase belong to the aldo-keto reductase superfamily, we named these human clones HAKRa to HAKRd. |
1(0,0,0,1) | Details |
| 8194472 | Albarracin CT, Parmer TG, Duan WR, Nelson SE, Gibori G: Identification of a major prolactin-regulated protein as 20 alpha-hydroxysteroid dehydrogenase: coordinate regulation of its activity, protein content, and messenger ribonucleic acid expression. Endocrinology. 1994 Jun;134(6):2453-60. The 37K protein showed sequence similarity with rabbit 20 alpha-hydroxysteroid dehydrogenase (20 alpha HSD), chlordecone reductase, prostaglandin synthase, and 3 alpha-hydroxysteroid dehydrogenase, which are members of the aldo-keto reductase group of enzymes that catalyze the -dependent reduction of carbonyl compounds. |
1(0,0,0,1) | Details |
| 10619355 | Lin HK, Hung CF, Moore M, Penning TM: Genomic structure of rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD, AKR1C9). J Steroid Biochem Mol Biol. 1999 Nov;71(1-2):29-39. Rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD) is a member of the aldo-keto reductase (AKR) superfamily. |
1(0,0,0,1) | Details |