| Name | neurotoxic esterase |
|---|---|
| Synonyms | NTE; SWS; Neuropathy target esterase; Neurotoxic esterase; PNPLA 6; patatin like phospholipase domain containing 6; Neuropathy target esterases… |
| Name | fenthion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2453943 | Farage-Elawar M, Francis BM: Effects of fenthion, fenitrothion and desbromoleptophos on gait, acetylcholinesterase, and neurotoxic esterase in young chicks after in ovo exposure. Toxicology. 1988 May;49(2-3):253-61. |
7(0,0,1,2) | Details |
| 2449534 | Farage-Elawar M, Francis BM: Effects of multiple dosing of fenthion, fenitrothion, and desbromoleptophos in young chicks. J Toxicol Environ Health. 1988;23(2):217-28. The effects of multiple doses of desbromoleptophos, fenitrothion, and pure fenthion on brain acetylcholinesterase (AChE), brain neurotoxic esterase (NTE), and walking were investigated in immature chicks, below the age of sensitivity to organophosphorus ester-induced delayed neurotoxicity (OPIDN). |
6(0,0,1,1) | Details |
| 2439699 | Farage-Elawar M, Francis BM: Acute and delayed effects of fenthion in young chicks. J Toxicol Environ Health. 1987;21(4):455-69. The effects of desbromoleptophos, fenitrothion, and fenthion on brain acetylcholinesterase (AChE), brain neurotoxic esterase (NTE), and walking were investigated in immature chicks, below the age of organophosphorus ester-induced delayed neurotoxicity (OPIDN). |
6(0,0,1,1) | Details |
| 8523492 | De Bleecker JL: The intermediate syndrome in organophosphate poisoning: an overview of experimental and clinical observations. J Toxicol Clin Toxicol. 1995;33(6):683-6. The intermediate syndrome of organophosphate poisoning arises in the time interval between the acute cholinergic crisis of fasciculations and muscle weakness and the delayed neuropathy attributed to inhibition of the neuropathy target esterase. |
1(0,0,0,1) | Details |
| 11884237 | Quistad GB, Sparks SE, Segall Y, Nomura DK, Casida JE: Selective inhibitors of fatty acid amide hydrolase relative to neuropathy target esterase and acetylcholinesterase: toxicological implications. Toxicol Appl Pharmacol. 2002 Feb 15;179(1):57-63. These FAAH-selective compounds include tribufos and (R)-octylbenzodioxaphosphorin oxide with delayed effects in mice and hens plus several organophosphorus pesticides (e.g., fenthion) implicated as delayed neurotoxicants in humans. |
2(0,0,0,2) | Details |
| 8511793 | Veronesi B, Ehrich M: Differential cytotoxic sensitivity in mouse and human cell lines exposed to organophosphate insecticides. Toxicol Appl Pharmacol. 1993 Jun;120(2):240-6. Baseline activities of the major target esterases, i.e., cholinesterase, carboxylesterase, and neurotoxic esterase, were assayed in mouse and several human neural candidate cell lines. IC50 data indicated that the tested mouse cell line was consistently more sensitive than the human cell line to equimolar doses of various OP compounds (e.g., mipafox, parathion, paraoxon, DFP, leptophos oxon, fenthion, and fenitrothion). |
1(0,0,0,1) | Details |
| 10321902 | Barber D, Correll L, Ehrich M: Comparative effectiveness of organophosphorus protoxicant activating systems in neuroblastoma cells and brain homogenates. J Toxicol Environ Health A. 1999 May 14;57(1):63-74. The ability of and rat liver microsomes (RLM) to convert organophosphorus (OP) protoxicants to esterase inhibitors was determined by measuring acetylcholinesterase (AChE) and neuropathy target esterase (NTE) inhibition. OP protoxicants examined included tri-o-tolyl (TOTP), O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN), leptophos, fenitrothion, fenthion, and malathion. |
1(0,0,0,1) | Details |
| 2462700 | Cherniack MG: Toxicological screening for organophosphorus-induced delayed neurotoxicity: complications in toxicity testing. Neurotoxicology. 1988 Summer;9(2):249-71. These were leptophos, fenthion, and isofenphos. |
0(0,0,0,0) | Details |
| 10509433 | Tuler SM, Bowen JM: Chronic fenthion toxicity in laying hens. Vet Hum Toxicol. 1999 Oct;41(5):302-7. |
0(0,0,0,0) | Details |
| 16042503 | Lotti M, Moretto A: Organophosphate-induced delayed polyneuropathy. . Toxicol Rev. 2005;24(1):37-49. Neuropathy target esterase (NTE) is thought to be the target of OPIDP initiation. We also discuss case reports where neuropathies were not convincingly attributed to fenthion, malathion, omethoate/dimethoate, parathion and merphos. |
1(0,0,0,1) | Details |