| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | fenthion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19111563 | Lavado R, Rimoldi JM, Schlenk D: Mechanisms of fenthion activation in rainbow trout (Oncorhynchus mykiss) acclimated to hypersaline environments. Toxicol Appl Pharmacol. 2009 Mar 1;235(2):143-52. Epub 2008 Dec 9. Stereochemical evaluation of sulfoxide formation, cytochrome P450 inhibition studies with ketoconazole and immunoblots indicated that CYP3A27 was primarily involved in the enhancement of fenthion activation in hypersaline-acclimated fish with limited contribution of FMO to initial sulfoxidation. |
31(0,1,1,1) | Details |
| 12527698 | Kitamura S, Suzuki T, Kadota T, Yoshida M, Ohashi K, Ohta S: In vitro metabolism of fenthion and fenthion sulfoxide by liver preparations of sea bream, goldfish, and rats. Drug Metab Dispos. 2003 Feb;31(2):179-86. Thus, fenthion and fenthion sulfoxide are interconvertible in fish and rats through the activities of cytochrome P450, flavin-containing monooxygenase, and aldehyde oxidase. |
7(0,0,1,2) | Details |
| 12676606 | Kitamura S, Suzuki T, Ohta S, Fujimoto N: Antiandrogenic activity and metabolism of the organophosphorus pesticide fenthion and related compounds. Environ Health Perspect. 2003 Apr;111(4):503-8. The oxidase activity toward fenthion was exhibited by cytochrome P450 and flavin-containing monooxygenase. |
6(0,0,1,1) | Details |
| 12495187 | Rodriguez MM, Bisset J, Ruiz M, Soca A: Cross-resistance to pyrethroid and organophosphorus insecticides induced by selection with temephos in Aedes aegypti (Diptera: Culicidae) from Cuba. J Med Entomol. 2002 Nov;39(6):882-8. Synergism tests implicated detoxifying esterases in temephos and fenthion resistance and deltamethrin resistance was associated with a cytochrome P450 monooxygenasa. |
6(0,0,1,1) | Details |
| 9461846 | Bride JM, Cuany A, Amichot M, Brun A, Babault M, Mouel TL, De Sousa G, Rahmani R, Berge JB: Cytochrome P-450 field insecticide tolerance and development of laboratory resistance in grape vine populations of Drosophila melanogaster (Diptera: Drosophilidae). J Econ Entomol. 1997 Dec;90(6):1514-20. Moreover, immunoblotting responses of microsomal protein encoded by Cyp6A2 showed that the levels of expression were quantitatively correlated with toxicological tolerance to almost the same group of insecticides (deltamethrin, fipronil, chlorpyriphos ethyl, DDT, fenvalerate, and fenthion). |
2(0,0,0,2) | Details |
| 15547051 | Furnes B, Schlenk D: Extrahepatic metabolism of and organophosphate thioether compounds by the flavin-containing monooxygenase and cytochrome P450 systems. Drug Metab Dispos. 2005 Feb;33(2):214-8. Epub 2004 Nov 16. Stereoselective sulfoxidation of fenthion and methiocarb by human liver, kidney, and microsomes was investigated. |
2(0,0,0,2) | Details |
| 18845175 | Leoni C, Buratti FM, Testai E: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol Appl Pharmacol. 2008 Dec 1;233(2):343-52. Epub 2008 Sep 19. In this study the in vitro human hepatic FEN biotransformation was characterized, identifying the relative contributions of cytochrome P450 (CYPs) and/or flavin-containing monooxygenase (FMOs) by using single c-DNA expressed human enzymes, human liver microsomes and cytosol and CYP/FMO-specific inhibitors. |
1(0,0,0,1) | Details |
| 8511793 | Veronesi B, Ehrich M: Differential cytotoxic sensitivity in mouse and human cell lines exposed to organophosphate insecticides. Toxicol Appl Pharmacol. 1993 Jun;120(2):240-6. IC50 data indicated that the tested mouse cell line was consistently more sensitive than the human cell line to equimolar doses of various OP compounds (e.g., mipafox, parathion, paraoxon, DFP, leptophos oxon, fenthion, and fenitrothion). B-lymphoblastoids, genetically engineered with human P450 cDNAs, demonstrated higher cytotoxic sensitivity to parathion than unengineered cells, indicating that cytochrome P450-associated monooxidase activity could also influence cytotoxic sensitivity to parathion in culture. |
1(0,0,0,1) | Details |
| 3794990 | Miyaoka T, Tsuda S, Shirasu Y: Mechanism of potentiation of BPMC toxicity by fenthion pretreatment in mice. J Pharmacobiodyn. 1986 Sep;9(9):697-703. |
0(0,0,0,0) | Details |