Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name fenvalerate
CAS cyano(3-phenoxyphenyl)methyl 4-chloro-α-(1-methylethyl)benzeneacetate

Reference List

PubMed Abstract RScore(About this table)
1651727 Reddy PM, Philip GH, Bashamohideen M: Inhibition of Mg2+ and Na (+)-K+ ATPases in selected tissues of fish, Cyprinus carpio under fenvalerate toxicity. Biochem Int. 1991 Mar;23(4):715-21.

Mg2+ ATPase and Na (+)-K+ ATPase activities were inhibited in all the tissues of fenvalerate exposed fish.
87(1,1,2,2) Details
1833318 Rao KV, Ghouselazam S, Surendranath P: Inhibition and recovery of selected target enzyme activities in tissues of penaeid prawn, Metapenaeus monoceros (Fabricius), exposed to different insecticides. Indian J Exp Biol. 1991 May;29(5):489-91.

The target enzymes, acetylcholinesterase (for phosphamidon and carbaryl) and Mg2+ ATPase (for DDT and fenvalerate) have been assayed during exposure and reclamation of these insecticides in M. monoceros.
31(0,1,1,1) Details
8385837 Malaviya M, Husain R, Seth PK, Husain R: Perinatal effects of two pyrethroid insecticides on brain neurotransmitter function in the neonatal rat. Vet Hum Toxicol. 1993 Apr;35(2):119-22.

These pups also showed a significant decrease in the activity of brain monoamine oxidase and Na+, K (+)-ATPase and a significant increase in acetylcholinesterase from gestational exposure to fenvalerate.
12(0,0,2,2) Details
17215890 Aurade R, Jayalakshmi SK, Sreeramulu K: Stimulatory effect of insecticides on partially purified P-glycoprotein ATPase from the resistant pest Helicoverpa armigera. Biochem Cell Biol. 2006 Dec;84(6):1045-50.

The partially purified Ha-Pgp ATPase was reconstituted into proteoliposomes and it was found that some insecticides, namely, monocrotophos, endosulfan, cypermethrin, fenvalerate, and methylparathion, stimulated the ATPase activity.
9(0,0,1,4) Details
15454122 Garg UK, Pal AK, Jha GJ, Jadhao SB: Haemato-biochemical and immuno-pathophysiological effects of chronic toxicity with synthetic pyrethroid, organophosphate and chlorinated pesticides in broiler chicks. Int Immunopharmacol. 2004 Dec 15;4(13):1709-22.

The total ATPase activity was enhanced (P <0.01) in fenvalerate and monocrotophos than birds in control group.
6(0,0,1,1) Details
14989895 He J, Chen JF, Liu R, Wang YB, Wang XR: [Effect of fenvalerate on the ovarian calcium homeostasis and the serum steroid hormone]. Zhonghua Yu Fang Yi Xue Za Zhi. 2004 Jan;38(1):18-21.

The activity of ovarian Ca (2+)-ATPase and phosphorylase A (P-a) and the contents of calmodulin (CaM) were assessed after a 30-day Fen exposure.
2(0,0,0,2) Details
17490606 Sreeramulu K, Liu R, Sharom FJ: Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function. Biochim Biophys Acta. 2007 Jul;1768(7):1750-7. Epub 2007 Apr 5.

We studied the effects of four commonly used insecticides (methylparathion, endosulfan, cypermethrin and fenvalerate) on P-glycoprotein isolated from multidrug-resistant cells.
All the pesticides stimulated P-glycoprotein ATPase activity, with maximum stimulation of up to 213% in a detergent-solubilized preparation, and up to 227% in reconstituted liposomes.
2(0,0,0,2) Details
6454717 El-Sebae AH, Sherby SI, Mansour NA: Gossypol as an inducer or inhibitor in Spodoptera littoralis larvae. J Environ Sci Health B. 1981;16(2):167-78.

Gossypol stimulates ATPase at lower concentrations and inhibited it at higher concentrations.
The I50 for mitochondrial ATPase was 1.7 X 10 (-4) M, while the corresponding values for DDT and fenvalerate were 1.1 X 10 (-4) M and 7.0 X 10 (-4) M respectively.
1(0,0,0,1) Details