| Name | p38 |
|---|---|
| Synonyms | AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38… |
| Name | sulfur |
|---|---|
| CAS | sulfur |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20143454 | Ruff AL, Dillman JF 3rd: Sulfur mustard induced cytokine production and cell death: Investigating the potential roles of the p38, p53, and NF-kappaB signaling pathways with RNA interference. J Biochem Mol Toxicol. 2010 Feb 8. |
81(1,1,1,1) | Details |
| 19969459 | Jerome KD, Rucker PV, Xing L, Shieh HS, Baldus JE, Selness SR, Letavic MA, Braganza JF, McClure KF: Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition. Bioorg Med Chem Lett. 2010 Jan 15;20(2):469-73. Epub 2009 Nov 26. The structure based drug design, synthesis and structure-activity relationship of a series of C6 sulfur linked triazolopyridine based p38 inhibitors are described. |
32(0,1,1,2) | Details |
| 19961386 | Imai T, Ii H, Yaegaki K, Murata T, Sato T, Kamoda T: Oral malodorous compound inhibits osteoblast proliferation. J Periodontol. 2009 Dec;80(12):2028-34. Previous studies demonstrated that volatile sulfur compounds (VSCs) were highly toxic to periodontal tissues, causing a large reduction in the amount of collagen in human gingival fibroblasts and extracellular matrix as well as, for example, apoptosis, immunologic responses, and matrix metalloproteinase production. The effects of H2S on the signal transduction pathways, the MAPK cascade, that control cell proliferation were evaluated in NHOst by determining extracellular signal-regulated kinase (ERK) 1/2 and p38 phosphorylation with a Western blot analysis. |
3(0,0,0,3) | Details |
| 19761830 | Pal A, Tewari-Singh N, Gu M, Agarwal C, Huang J, Day BJ, White CW, Agarwal R: Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice. Free Radic Biol Med. 2009 Dec 1;47(11):1640-51. Epub 2009 Sep 15. CEES exposure instigated an increase in the phosphorylation of mitogen-activated protein kinases (MAPKs; ERK1/2, JNK, and p38). |
1(0,0,0,1) | Details |
| 19497413 | Das A, Bortner J, Desai D, Amin S, El-Bayoumy K: The analog of the chemopreventive compound S,S'-(1,4-phenylenebis [1,2-ethanediyl]) bisisothiourea is a remarkable inducer of apoptosis and inhibitor of cell growth in human non-small cell lung cancer. Chem Biol Interact. 2009 Jul 15;180(2):158-64. Epub 2009 Mar 20. Previous studies have suggested that substitution of sulfur by in established cancer chemopreventive agents may result in more effective analogs. |
0(0,0,0,0) | Details |
| 20091890 | Hui C, Like W, Yan F, Tian X, Qiuyan W, Lifeng H: S-allyl- sulfoxide inhibits tumor necrosis factor-alpha induced monocyte adhesion and intercellular cell adhesion molecule-1 expression in human umbilical vein endothelial cells. Anat Rec. 2010 Mar;293(3):421-30. Garlic and its water-soluble allyl sulfur-containing compound, S-Allyl- Sulfoxide (ACSO), have shown antioxidant and anti-inflammatory activities, inhibiting the development of atherosclerosis. |
0(0,0,0,0) | Details |
| 19464336 | Mukhopadhyay S, Mukherjee S, Stone WL, Smith M, Das SK: Role of MAPK/AP-1 signaling pathway in the protection of CEES-induced lung injury by antioxidant liposome. Toxicology. 2009 Jul 10;261(3):143-51. Epub 2009 May 21. The maximum protection was achieved with a liposome composed of (alpha, gamma, delta) and (NAC) when administered after 5 min of exposure of 2-chloroethyl ethyl sulfide (CEES), a half sulfur mustard gas. |
0(0,0,0,0) | Details |