| Name | CYP1A1 |
|---|---|
| Synonyms | AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1… |
| Name | diuron |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17576805 | Abass K, Reponen P, Turpeinen M, Jalonen J, Pelkonen O: Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymes. Drug Metab Dispos. 2007 Sep;35(9):1634-41. Epub 2007 Jun 18. All tested recombinant human cytochrome P450s (P450s) catalyzed diuron N-demethylation and the highest activities were possessed by CYP1A1, CYP1A2, CYP2C19, and CYP2D6. |
162(2,2,2,2) | Details |
| 16788953 | Zhao B, Baston DS, Hammock B, Denison MS: Interaction of diuron and related substituted phenylureas with the Ah receptor pathway. J Biochem Mol Toxicol. 2006;20(3):103-13. Diuron induced CYP1A1 mRNA levels in mouse hepatoma (Hepa1c1c7) cells and AhR-dependent luciferase reporter gene expression in stably transfected mouse, rat, guinea pig, and human cell lines. |
6(0,0,1,1) | Details |
| 18835618 | Takeuchi S, Iida M, Yabushita H, Matsuda T, Kojima H: In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A induction by propanil, diuron and linuron. Chemosphere. 2008 Dec;74(1):155-65. Epub 2008 Oct 5. To investigate the in vivo effects, we examined the gene expression of AhR-inducible cytochrome P450 1As (CYP1As) in the liver of female C57BL/6 mice intraperitoneally injected with these three herbicides (300 mg kg (-1)) by quantitative RT-PCR, resulting in induction of significant high levels of CYP1A1 and CYP1A2 mRNAs. |
1(0,0,0,1) | Details |