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diuron

Identification (Source:EPA,EU)

ID	318
Name	diuron
CAS	330-54-1
IUPAC	3-(3,4-dichlorophenyl)-1,1-dimethylurea
Inchi	InChI=1S/C9H10Cl2N2O/c1-13(2)9(14)12-6-3-4-7(10)8(11)5-6/h3-5H,1-2H3,(H,12,14)
CIPAC	100
EPA Code	035505
Formula	C9H10Cl2N2O
SMILES	Clc1ccc(NC(=O)N(C)C)cc1Cl
Status	Approved

Classification

Mode of Action	Systemic, absorbed via roots, acts by strongly inhibiting photosynthesis
Pesticide Type	Herbicide
Chemical Group	Phenylurea
Classification	phenylurea herbicides Algicides

Properties (Source:PubChem)

Molecular Weight	233.09
Physical State	Off-white powder
AlogP	2.48
H-Bond Donor	1
H-Bond Acceptor	1
Surface Area	225.25
Polar Surface Area	32.34

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	0.0027 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	1.1 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	5.7 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.096 mg l-1
Aquatic plants	Acute	7 day	EC50, biomass	0.0183 mg l-1
Birds	Short term dietary		LC50/LD50	1730 mg/kg feed
Birds	Acute		LD50	1104 mg kg-1
Earthworms	Acute	14 day	LD50	> 798 mg kg-1
Earthworms	Chronic	14 day	NOEC, reproduction	14.4 mg kg-1
Fish	Chronic	21 day	NOEC	0.41 mg l-1
Fish	Acute	96 hour	LC50	6.7 mg l-1
Honeybees	Acute	48 hour	LD50	> 100 μg bee-1
Mammals	Acute oral		LD50	437 mg kg-1
Mammals	Short term dietary		NOEL	> 250 ppm diet
	Bio-concentration factor		CT50	Not available days

Related targets

Target Name	RScore (About this table)
cytochrome b	570(5,7,14,75)	Details
Ah receptor	275(2,5,7,15)	Details
CYP1A1	169(2,2,3,4)	Details
protein as	115(1,2,2,5)	Details
CYP1A2	113(1,2,2,3)	Details
CYP2C19	112(1,2,2,2)	Details
C18	128(1,1,5,28)	Details
cytochrome P450 (protein family or complex)	96(1,1,2,11)	Details
CP47	96(1,1,1,16)	Details
protein is	93(1,1,1,13)	Details
ps 2	86(1,1,1,6)	Details
protoporphyrinogen oxidase	85(1,1,1,5)	Details
K15	85(1,1,1,5)	Details
cytochrome bc1	82(1,1,1,2)	Details
beta glucosidase	81(1,1,1,1)	Details
AHAS	81(1,1,1,1)	Details
ubiquinol cytochrome c reductase (protein family or complex)	81(1,1,1,1)	Details
CYP2D6	81(1,1,1,1)	Details
b protein	102(0,3,3,12)	Details
cytochrome c	48(0,1,2,13)	Details
Koc	44(0,1,2,9)	Details
Tyrosinase	41(0,1,2,6)	Details
hemoglobin (protein family or complex)	38(0,1,1,8)	Details
CCT	37(0,1,2,2)	Details
cytochrome c1	35(0,1,1,5)	Details
quinone reductase	33(0,1,1,3)	Details
cytochrome b 561	33(0,1,1,3)	Details
calmodulin	32(0,1,1,2)	Details
leucine aminopeptidase	32(0,1,1,2)	Details
demethylases	32(0,1,1,2)	Details
CYP3A4	31(0,1,1,1)	Details
Acetylcholinesterase	24(0,0,2,14)	Details
single chain Fv fragments	18(0,0,2,8)	Details
ATPase	14(0,0,0,14)	Details

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