Protein Information

Name cytochrome P450 (protein family or complex)
Synonyms cytochrome P450; cytochrome P 450; CYP450; CYP 450

Compound Information

Name diuron
CAS

Reference List

PubMed Abstract RScore(About this table)
17576805 Abass K, Reponen P, Turpeinen M, Jalonen J, Pelkonen O: Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymes. Drug Metab Dispos. 2007 Sep;35(9):1634-41. Epub 2007 Jun 18.
81(1,1,1,1) Details
18835618 Takeuchi S, Iida M, Yabushita H, Matsuda T, Kojima H: In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A induction by propanil, diuron and linuron. Chemosphere. 2008 Dec;74(1):155-65. Epub 2008 Oct 5.
7(0,0,1,2) Details
11986683 : NTP Technical Report on the Toxicity Studies of 3,3',4,4'-Tetrachloroazoxybenzene (CAS No. 21232-47-3) Administered by Gavage to F344/N Rats and B6C3F1 Mice. Toxic Rep Ser. 1998 Nov;66:1-G4.

3,3',4,4'-Tetrachloroazoxybenzene is not commercially manufactured but is present as a contaminant of 3,4-dichloroaniline and its herbicidal derivative Diuron (R).
In addition to histopathology, evaluations included hematology (rats only), clinical chemistry, thyroid hormone analyses (rats only), hepatic cell proliferation (rats only), cytochrome P (450) 1A immunohistological staining in the liver (rats only), and assessments of male reproductive endpoints and estrous cycle length.
3(0,0,0,3) Details
11986682 : NTP Technical Report on the Toxicity Studies of 3,3',4,4'-Tetrachloroazobenzene (CAS No. 14047-09-7) Administered by Gavage to F344/N Rats and B6C3F1 Mice. Toxic Rep Ser. 1998 Nov;65:1-F6.

3,3',4,4'-Tetrachloroazobenzene is not commercially manufactured but is formed as an unwanted byproduct in the manufacture of 3,4-dichloroaniline and its herbicidal derivatives Propanil (R), Linuron (R), and Diuron (R).
In addition to histopathology, evaluations included hematology (rats only), clinical chemistry, thyroid hormone analyses (rats only), cytochrome P (450) 1A immunohistochemical staining in the liver (rats only), and assessments of male reproductive endpoints and estrous cycle length.
3(0,0,0,3) Details
2979785 Schoket B, Zilahy Z, Molnar J, Vincze I: Comparative investigation of antipyrine half-life and induction of cytochrome P-450 dependent monooxygenases in rats treated with phenylurea herbicides. In Vivo. 1987 May-Jun;1(3):185-7.

Isoproturon was ineffective, while chlortoluron and diuron decreased the half-life significantly.
2(0,0,0,2) Details