Protein Information

Name demethylase
Synonyms DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases…

Compound Information

Name epoxiconazole
CAS

Reference List

PubMed Abstract RScore(About this table)
19496952 Madoui MA, Bertrand-Michel J, Gaulin E, Dumas B: Sterol metabolism in the oomycete Aphanomyces euteiches, a legume root pathogen. New Phytol. 2009;183(2):291-300. Epub 2009 Jun 3.

Mycelium development is inhibited by two sterol demethylase inhibitors used as fungicides, namely tebuconazole and epoxiconazole.
31(0,1,1,1) Details
15276168 Trosken ER, Straube E, Lutz WK, Volkel W, Patten C: Quantitation of lanosterol and its major metabolite FF-MAS in an inhibition assay of CYP51 by azoles with atmospheric pressure photoionization based LC-MS/MS. J Am Soc Mass Spectrom. 2004 Aug;15(8):1216-21.

IC (50) values of epoxiconazole and miconazole-two widely used azole fungicides used in agriculture and in human medicine, respectively-were 1.95 microM and 0.057 microM.
Lanosterol 14alpha-demethylase (CYP51) is an enzyme inhibited by azoles.
1(0,0,0,1) Details
15933029 Reimann S, Deising HB: Inhibition of efflux transporter-mediated fungicide resistance in Pyrenophora tritici-repentis by a derivative of 4'-hydroxyflavone and enhancement of fungicide activity. Appl Environ Microbiol. 2005 Jun;71(6):3269-75.


Populations of the causal agent of wheat tan spot, Pyrenophora tritici-repentis, that are collected from fields frequently treated with reduced fungicide concentrations have reduced sensitivity to strobilurin fungicides and azole fungicides (C14-demethylase inhibitors).
1(0,0,0,1) Details