| 16315095 |
Kawahigashi H, Hirose S, Ozawa K, Ido Y, Kojima M, Ohkawa H, Ohkawa Y: Analysis of substrate specificity of pig CYP2B22 and CYP2C49 towards herbicides by transgenic rice plants. Transgenic Res. 2005 Dec;14(6):907-17.
We introduced two novel types of pig (Sus scrofa) cytochrome P450, CYP2B22 and CYP2C49, into rice plants (Oryza sativa L. cv. 'Nipponbare') to produce herbicide-tolerant plants and to confirm the metabolic activities of the cytochrome P450 species.
CYP2B22 rice plants showed tolerance towards 12 herbicides including chlortoluron (100 microM), amiprofos-methyl (2.5 microM), pendimethalin (10 microM), metolachlor (2.5 microM), and esprocarb (20 microM). |
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