| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | fenarimol |
|---|---|
| CAS | α-(2-chlorophenyl)-α-(4-chlorophenyl)-5-pyrimidinemethanol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18372651 | Zeiman E, Greenblatt CL, Elgavish S, Khozin-Goldberg I, Golenser J: Mode of action of fenarimol against Leishmania spp. J Parasitol. 2008 Feb;94(1):280-6. Fenarimol impairs the function of leishmanial 14alpha-sterol demethylase, a key enzyme in the sterol biosynthetic pathway. |
162(2,2,2,2) | Details |
| 8628233 | van Nistelrooy JG, van den Brink JM, van Kan JA, van Gorcom RF, de Waard MA: Isolation and molecular characterisation of the gene encoding eburicol 14 alpha-demethylase (cYP51) from Penicillium italicum. Mol Gen Genet. 1996 Apr 10;250(6):725-33. |
3(0,0,0,3) | Details |
| 19132812 | Hassold E, Backhaus T: Chronic toxicity of five structurally diverse demethylase-inhibiting fungicides to the crustacean Daphnia magna: a comparative assessment. Environ Toxicol Chem. 2009 Jun;28(6):1218-26. Therefore, we selected a representative of each of the major DMI classes--the piperazine triforine, the pyrimidine fenarimol, the pyrifenox, the prochloraz, and the triazole triadimefon--and comparatively investigated their chronic toxicity to Daphnia magna. |
2(0,0,0,2) | Details |
| 7722883 | Lodovici M, Aiolli S, Monserrat C, Dolara P, Medica A, Di Simplicio P: Effect of a mixture of 15 commonly used pesticides on DNA levels of and xenobiotic metabolizing enzymes in rat liver. J Environ Pathol Toxicol Oncol. 1994;13(3):163-8. The level of 8-OH- in rat liver DNA was measured as an index of oxidative damage after treating rats for 10 days at a dose ranging from 0.75 to 10 mg/kg with a mixture of 15 pesticides (dithiocarbamate, benomyl, thiabendazole, diphenylamine, chlorthalonil, procimidone, methidathion, chlorpyrifos-ethyl, fenarimol, parathion-methyl, chlorpropham, parathion, vinclozolin, chlorfenvinphos, pirimiphos-ethyl) commonly found in foods of central Italy. The administration of the pesticide mixture dose dependently reduced benzo (a) pyrene hydroxylase, N-demethylase activities, peroxidase, glutathione reductase, glutathione-S-transferase and thiol transferase activities in the liver. |
1(0,0,0,1) | Details |