Protein Information

Name protein is
Synonyms ANX 2; p36; LIP 2; LIP2; ANX2; ANX2L4; ANX2P1; ANX2P2…

Compound Information

Name ioxynil
CAS 4-hydroxy-3,5-diiodobenzonitrile

Reference List

PubMed Abstract RScore(About this table)
9654132 Elanskaya IV, Chesnavichene EA, Vernotte C, Astier C: Resistance to nitrophenolic herbicides and metronidazole in the cyanobacterium Synechocystis sp. FEBS Lett. 1998 May 29;428(3):188-92.

PCC 6803 the DrgA protein is involved in detoxification of dinoseb via the reduction of the nitro group (s) and this process is accompanied by the formation of toxic superoxide anions.
PCC 6803, selected for resistance to dinoseb, and the mutant Ins2, constructed by the insertion of the kanamycin resistance cassette into the drgA gene, were cross-resistant to other nitrophenolic herbicides (DNOC, 2,4-dinitrophenol) and to the cell inhibitor metronidazole but not to the photosystem II inhibitors DCMU or ioxynil.
1(0,0,0,1) Details
16735503 Yoshioka M, Uchida S, Mori H, Komayama K, Ohira S, Morita N, Nakanishi T, Yamamoto Y: Quality control of photosystem II. J Biol Chem. 2006 Aug 4;281(31):21660-9. Epub 2006 May 30.

Herbicides 3-(3,4-dichlorophenyl)-1,1-dimethyl urea, bromoxynil, and ioxynil, all of which bind to the Q (B) site, inhibited the D1 cleavage, suggesting that the DE-loop of the D1 protein is the heat-sensitive cleavage site.
81(1,1,1,1) Details
2116129 Creuzet S, Ajlani G, Vernotte C, Astier C: A new ioxynil-resistant mutant in Synechocystis PCC 6714: hypothesis on the interaction of ioxynil with the D 1 protein. Z Naturforsch C. 1990 May;45(5):436-40.

The mutation found in the psbA gene (encoding the D 1 photosystem II protein) is at the same codon 266 as for the first ioxynil-resistant mutant IoxIA previously selected [G.
6(0,0,1,1) Details
2669780 Oettmeier W, Masson K, Hohfeld J, Meyer HE, Pfister K, Fischer HP: [125I] azido-ioxynil labels Val249 of the photosystem II D-1 reaction center protein. Z Naturforsch C. 1989 May-Jun;44(5-6):444-9.

A 41 kDa protein is only tagged in trace amounts.
1(0,0,0,1) Details
8425056 Bouyoub A, Vernotte C, Astier C: Functional analysis of the two homologous psbA gene copies in Synechocystis PCC 6714 and PCC 6803. Plant Mol Biol. 1993 Jan;21(2):249-58.


This protein is an essential subunit of photosystem II (PSII) and is the target for herbicides.
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7784425 Sobolev V, Edelman M: Modeling the quinone-B binding site of the photosystem-II reaction center using notions of complementarity and contact-surface between atoms. Proteins. 1995 Mar;21(3):214-25.


A model of the quinone (QB) binding site of the D1 protein is presented based upon the resolved structure of the QB binding pocket of the L subunit, and introducing novel quantitative notions of complementarity and contact surface between atoms.
1(0,0,0,1) Details