| Name | androgen receptor |
|---|---|
| Synonyms | AIS; AR; Androgen receptor; DHTR; Dihydrotestosterone receptor; HUMARA; KD; NR3C4… |
| Name | iprodione |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10188194 | Gray LE Jr, Wolf C, Lambright C, Mann P, Price M, Cooper RL, Ostby J: Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health. 1999 Jan-Mar;15(1-2):94-118. For example, in utero treatment with the androgen receptor (AR) antagonist, flutamide, produces ventral prostate agenesis and testicular nondescent, while in contrast, finasteride, an inhibitor of 5 alpha- (DHT) synthesis, rarely, if ever, induces such malformations. |
1(0,0,0,1) | Details |
| 19564212 | Blystone CR, Lambright CS, Cardon MC, Furr J, Rider CV, Hartig PC, Wilson VS, Gray LE Jr: Cumulative and antagonistic effects of a mixture of the antiandrogens vinclozolin and iprodione in the pubertal male rat. Toxicol Sci. 2009 Sep;111(1):179-88. Epub 2009 Jun 29. Here, we demonstrate that iprodione binds to the human androgen receptor (IC (50) = 86.0 microM), reduces androgen-dependent gene expression, and reduces androgen-sensitive tissue weights in castrated male rats (Hershberger assay). |
81(1,1,1,1) | Details |
| 15033008 | Zhang GJ, Zheng YF, Zhu HJ, Zhu XQ: [The antiandrogenic effect of dimethachlon and its mechanism] . Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):15-8. Six-week-old castrated male SD rats were administrated once daily for 7 days with testosterone propionate (TP, 100 micro g/d, sc) plus gavage doses of dimethachlon (50, 100 or 200 mg x kg (-1) x d (-1)), or procymidone (150 or 300 mg x kg (-1) x d (-1), positive control), or iprodione (100 mg x kg (-1) x d (-1), positive control), or flutamide (50 mg x kg (-1) x d (-1), positive control). Human hepatoma liver cells HepG2 were transiently cotransfected with human androgen receptor (AR) expression plasmid and AR-dependent luciferase report plasmid. |
1(0,0,0,1) | Details |
| 17931804 | Blystone CR, Lambright CS, Furr J, Wilson VS, Gray LE Jr: Iprodione delays male rat pubertal development, reduces serum levels, and decreases ex vivo testicular production. Toxicol Lett. 2007 Nov 1;174(1-3):74-81. Epub 2007 Aug 31. |
0(0,0,0,0) | Details |