Protein Information

Name p38
Synonyms AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38…

Compound Information

Name kinetin
CAS

Reference List

PubMed Abstract RScore(About this table)
9753691 Wang Z, Canagarajah BJ, Boehm JC, Kassisa S, Cobb MH, Young PR, Abdel-Meguid S, Adams JL, Goldsmith EJ: Structural basis of inhibitor selectivity in MAP kinases. Structure. 1998 Sep 15;6(9):1117-28.


The MAP kinase p38 is responsive to environmental stresses and is involved in the production of cytokines during inflammation.
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9792443 Forrer P, Tamaskovic R, Jaussi R: Enzyme-linked immunosorbent assay for measurement of JNK, ERK, and p38 kinase activities. Biol Chem. 1998 Aug-Sep;379(8-9):1101-11.

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9779816 Cheng TJ, Lai YK: Identification of mitogen-activated protein kinase-activated protein kinase-2 as a vimentin kinase activated by okadaic acid in 9L rat brain tumor cells. J Cell Biochem. 1998 Nov 1;71(2):169-81.


With specific protein kinase inhibitors, we show the possible involvement of the cdc2 kinase- and p38 mitogen-activated protein kinase (p38MAPK)-mediated pathways in this process.
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18262743 Berge U, Kristensen P, Rattan SI: Hormetic modulation of differentiation of normal human epidermal keratinocytes undergoing replicative senescence in vitro. Exp Gerontol. 2008 Jul;43(7):658-62. Epub 2008 Jan 10.

Using this experimental model system, we have studied age-related changes in the ability of serially passaged NHEK to enter into differentiation in the presence of calcium, as measured by the levels of differentiation markers involucrin, p38 and Hsp27.
The results obtained in these studies show that calcium-induced differentiation of NHEK becomes progressively delayed during cellular aging in vitro, which can be modulated by treatments such as mild heat stress, kinetin and curcumin.
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