| Name | ERbeta |
|---|---|
| Synonyms | ER beta; ERb; ERbeta; ESR beta; ESR 2; ESR2; ESRB; ESRbeta… |
| Name | methoxychlor |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-methoxybenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10999957 | Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S: Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Mol Pharmacol. 2000 Oct;58(4):852-8. We previously demonstrated differential interactions of the methoxychlor metabolite 2,2-bis (p-hydroxyphenyl)-1,1, 1-trichloroethane (HPTE) with estrogen receptor alpha (ERalpha), ERbeta, and the androgen receptor (AR). |
196(2,3,3,6) | Details |
| 10579340 | Gaido KW, Leonard LS, Maness SC, Hall JM, McDonnell DP, Saville B, Safe S: Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. Endocrinology. 1999 Dec;140(12):5746-53. We compared the activity of 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), an estrogenic metabolite of the organochlorine pesticide methoxychlor, at estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta). |
34(0,1,1,4) | Details |
| 10537130 | Roy D, Angelini NL, Belsham DD: directly respresses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons. Endocrinology. 1999 Nov;140(11):5045-53. The recently reported ERalpha-specific agonist/ERbeta-specific antagonist 2,2-bis-(p-hydroxyphenyl-1,1,1-trichloroethane (HPTE), a methoxychlor metabolite, also down-regulated GnRH gene expression. |
33(0,1,1,3) | Details |
| 10433208 | Ghosh D, Taylor JA, Green JA, Lubahn DB: Methoxychlor stimulates -responsive messenger ribonucleic acids in mouse uterus through a non-estrogen receptor (non-ER) alpha and non-ER beta mechanism. Endocrinology. 1999 Aug;140(8):3526-33. |
31(0,1,1,1) | Details |
| 11509743 | Waters KM, Safe S, Gaido KW: Differential gene expression in response to methoxychlor and through ERalpha, ERbeta, and AR in reproductive tissues of female mice. Toxicol Sci. 2001 Sep;63(1):47-56. |
8(0,0,1,3) | Details |
| 9751507 | Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology. 1998 Oct;139(10):4252-63. All environmental estrogenic chemicals [polychlorinated hydroxybiphenyls, dichlorodiphenyltrichloroethane (DDT) and derivatives, alkylphenols, bisphenol A, methoxychlor and chlordecone] compete with E2 for binding to both ER subtypes with a similar preference and degree. |
8(0,0,0,8) | Details |
| 9492041 | Petersen DN, Tkalcevic GT, Koza-Taylor PH, Turi TG, Brown TA: Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues. Endocrinology. 1998 Mar;139(3):1082-92. However, a variety of known estrogenic agents, including physiological estrogens and plant and environmental estrogens coumestrol, bisphenol A, methoxychlor), and pharmocological agents (tamoxifen, 4-hydroxytamoxifen) did effectively compete for binding to both ER beta1 and ER beta2. |
5(0,0,0,5) | Details |
| 19589859 | Zama AM, Uzumcu M: Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes. Endocrinology. 2009 Oct;150(10):4681-91. Epub 2009 Jul 9. Previous studies showed that fetal/neonatal exposure to MXC caused adult ovarian dysfunction due to altered expression of key ovarian genes including estrogen receptor (ER)-beta, which was down-regulated, whereas ERalpha was unaffected. |
3(0,0,0,3) | Details |
| 16626760 | Lemaire G, Mnif W, Mauvais P, Balaguer P, Rahmani R: Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines. Life Sci. 2006 Aug 15;79(12):1160-9. Epub 2006 Mar 27. In this report, forty-nine pesticides were tested for ERalpha and beta activation or inhibition in stable reporter cell lines, HELN ERalpha and ERbeta. Antagonistic activities toward hERalpha and hERbeta were shown in three (carbaryl, pentachlorophenol and 2,4,5-trichlorophenoxyacetic acid) and seven (chlordecone, methoxychlor, carbaryl, endosulfan, endrin, dieldrin, aldrin) pesticides, respectively. |
3(0,0,0,3) | Details |
| 17949972 | Blum JL, James MO, Stuchal LD, Denslow ND: Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells. J Steroid Biochem Mol Biol. 2008 Jan;108(1-2):55-63. Epub 2007 Sep 7. While it is clear the ERbeta subtypes are the products of different genes (due to a gene duplication in teleosts) the differences in their responses to MXC and its metabolites indicate that their functions diverge, both in their in vivo molecular response to E (2), as well as in their interaction with endocrine disrupting compounds found in the wild. |
1(0,0,0,1) | Details |
| 9118870 | Shelby MD, Newbold RR, Tully DB, Chae K, Davis VL: Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays. Environ Health Perspect. 1996 Dec;104(12):1296-300. The assays were 1) competitive binding with the mouse uterine estrogen receptor, 2) transcriptional activation in HeLa cells transfected with plasmids containing an estrogen receptor and a response element, and 3) the uterotropic assay in mice. The chemicals studied were 17 beta- diethylstilbestrol, tamoxifen, 4-hydroxytamoxifen, methoxychlor, the methoxychlor metabolite 2,2-bis (p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), endosulfan, nonylphenol, o,p'-DDT, and kepone. |
1(0,0,0,1) | Details |
| 11390175 | Cupp AS, Skinner MK: Actions of the endocrine disruptor methoxychlor and its estrogenic metabolite on in vitro embryonic rat seminiferous cord formation and perinatal testis growth. Reprod Toxicol. 2001 May-Jun;15(3):317-26. Immunohistochemical analysis localized ERalpha to the cells of the seminiferous cords at E14 though P5 while ERbeta was present in cells of the interstitium at E16 and P0. |
1(0,0,0,1) | Details |
| 15451043 | Golub MS, Germann SL, Hogrefe CE: Endocrine disruption and cognitive function in adolescent female rhesus monkeys. Neurotoxicol Teratol. 2004 Nov-Dec;26(6):799-809. Differential effects of the two agents at the estrogen receptor subtypes (ER alpha and ER beta) may be relevant to the differential behavioral outcomes. Female rhesus monkeys (n=8/group) received daily oral doses of exogenous [diethylstilbestrol (DES), 0.5 mg/kg, methoxychlor (MXC), 25 or 50 mg/kg] for 6 months before and after the anticipated age of menarche. |
1(0,0,0,1) | Details |
| 12730626 | Golub MS, Hogrefe CE, Germann SL, Lasley BL, Natarajan K, Tarantal AF: Effects of exogenous estrogenic agents on pubertal growth and reproductive system maturation in female rhesus monkeys. Toxicol Sci. 2003 Jul;74(1):103-13. Epub 2003 May 2. The pattern of effects across agents and doses may be based on specifics of estrogenic action, such as relative ERalpha and ERbeta binding and activation. This study examined the consequences of treatment with estrogenic agents (methoxychlor, MXC, 25 and 50 mg/kg/day; diethylstilbestrol, DES, 0.5 mg/kg/day) given in the peripubertal period (6 months before and after the expected age at menarche) to female rhesus monkeys. |
1(0,0,0,1) | Details |
| 18848953 | Armenti AE, Zama AM, Passantino L, Uzumcu M: Developmental methoxychlor exposure affects multiple reproductive parameters and ovarian folliculogenesis and gene expression in adult rats. Toxicol Appl Pharmacol. 2008 Dec 1;233(2):286-96. Epub 2008 Sep 24. Immunohistochemical staining and quantification of the staining intensity showed that estrogen receptor beta was reduced by high dose MXC while anti-Mullerian hormone was upregulated by both low- and high dose MXC in preantral and early antral follicles (P <0.05). |
1(0,0,0,1) | Details |
| 18279978 | Blum JL, Nyagode BA, James MO, Denslow ND: Effects of the pesticide methoxychlor on gene expression in the liver and testes of the male largemouth bass (Micropterus salmoides). Aquat Toxicol. 2008 Mar 26;86(4):459-69. Epub 2008 Jan 3. By 72 h, the MXC effects had disappeared, while E2 significantly decreased the expression of ER beta a mRNA. |
1(0,0,0,1) | Details |
| 16183386 | Takagi H, Shibutani M, Lee KY, Masutomi N, Fujita H, Inoue K, Mitsumori K, Hirose M: Impact of maternal dietary exposure to endocrine-acting chemicals on progesterone receptor expression in microdissected hypothalamic medial preoptic areas of rat offspring. Toxicol Appl Pharmacol. 2005 Oct 15;208(2):127-36. We have previously examined the impact of perinatal exposure to ethinylestradiol (EE), methoxychlor (MXC), diisononyl (DINP), and (GEN) in maternal diet on rat offspring, and found developmental and/or reproductive toxicity with 0.5 ppm EE, 1200 ppm MXC, and 20,000 ppm DINP. Sexually dimorphic expression of ER alpha and PR was noted with predominance in females and males, respectively, EE up-regulating SRC-1 in males and ER beta and PR in females. |
1(0,0,0,1) | Details |
| 9860891 | Gaido K, Dohme L, Wang F, Chen I, Blankvoort B, Ramamoorthy K, Safe S: Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food. Environ Health Perspect. 1998 Dec;106 Suppl 6:1347-51. The reconstituted organochlorine mixture contained 1,1,1-trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl) ethane, 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane, 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene, endosulfan-1, endosulfan-2, p,p'-methoxychlor, and toxaphene; the relative proportion of each chemical in the mixture resembled the composition reported in a recent U.S. The following battery of in vitro 17 (E2)-responsive bioassays were utilized in this study: competitive binding to mouse uterine estrogen receptor (ER); proliferation in T47D human breast cancer cells; luciferase (Luc) induction in human HepG2 cells transiently cotransfected with C3-Luc and the human ER, rat ER-alpha, or rat ER-beta; induction of chloramphenicol acetyltransferase (CAT) activity in MCF-7 human breast cancer cells transfected with E2-responsive cathepsin D-CAT or kinase B-CAT plasmids. |
1(0,0,0,1) | Details |
| 11432551 | Thorpe KL, Hutchinson TH, Hetheridge MJ, Scholze M, Sumpter JP, Tyler CR: Assessing the biological potency of binary mixtures of environmental estrogens using vitellogenin induction in juvenile rainbow trout (Oncorhynchus mykiss). Environ Sci Technol. 2001 Jun 15;35(12):2476-81. The estrogenic potencies of estradiol-17beta (E2), 4-tertnonylphenol (NP), and methoxychlor (MXC) were determined following 14 day exposures to the individual chemicals and binary mixtures of these chemicals. This suggests that while NP probably acts via the same mechanism as E2 in inducing VTG synthesis, MXC may be acting via a different mechanism (s), possibly as a result of its conversion to HPTE which is an estrogen receptor alpha agonist and an estrogen receptor beta antagonist. |
1(0,0,0,1) | Details |