| Name | CYP3A |
|---|---|
| Synonyms | CP33; CYP3; HLP; CYP3A; CP34; CYP 3A4; CYP 3; CYP3A3… |
| Name | methoxychlor |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-methoxybenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9714305 | Stresser DM, Kupfer D: Prosubstrates of CYP3A4, the major human hepatic cytochrome P450: transformation into substrates by other P450 isoforms. Biochem Pharmacol. 1998 Jun 1;55(11):1861-71. These findings demonstrate that pro-phenolic compounds (methoxychlor and 3-methyl ether) are prosubstrates of CYP3A4. |
11(0,0,1,6) | Details |
| 15466163 | Yueh MF, Kawahara M, Raucy J: High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line. Drug Metab Dispos. 2005 Jan;33(1):38-48. Epub 2004 Oct 1. Treatment of stable transformants, namely DPX-2, with various concentrations of inducers including rifampicin, mifepristone, troglitazone, methoxychlor, and kava produced dose-dependent increases in luciferase expression (between 2- and 40-fold above -treated cells). |
9(0,0,0,9) | Details |
| 14613717 | Mikamo E, Harada S, Nishikawa J, Nishihara T: Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor. Toxicol Appl Pharmacol. 2003 Nov 15;193(1):66-72. Pregnane X receptor (PXR) is a nuclear receptor that regulates the expression of genes for cytochrome P450 3A (CYP3A), multidrug resistance 1 (MDR1), and organic anion-transporting peptide 2 (OATP2). In our study, 7 of 54 xenobiotics compounds interacted with PXR, including methoxychlor and benzophenone. |
3(0,0,0,3) | Details |
| 12167570 | Hu Y, Kupfer D: Metabolism of the endocrine disruptor pesticide-methoxychlor by human P450s: pathways involving a novel metabolite. Drug Metab Dispos. 2002 Sep;30(9):1035-42. CYP3A4, 3A5, and rat 2B1 catalyzed primarily ortho-hydroxylation of mono-OH-M (CYP3A4 being catalytically the most active) but were weak in O-demethylation. |
1(0,0,0,1) | Details |
| 18279978 | Blum JL, Nyagode BA, James MO, Denslow ND: Effects of the pesticide methoxychlor on gene expression in the liver and testes of the male largemouth bass (Micropterus salmoides). Aquat Toxicol. 2008 Mar 26;86(4):459-69. Epub 2008 Jan 3. Total 6 beta-hydroxylase activity, reflective of CYP3A activity, was also increased by 24h for all of the exposures. |
1(0,0,0,1) | Details |
| 16054614 | Kretschmer XC, Baldwin WS: CAR and PXR: xenosensors of endocrine disrupters? . Chem Biol Interact. 2005 Aug 15;155(3):111-28. Furthermore, PXR and CAR induce enzymes, such as the CYP2B and CYP3A family members, responsible for the metabolism of steroid and thyroid hormones and this may alter their normal physiological function. Environmental estrogens, such as the pesticides methoxychlor, endosulfan, dieldrin, DDT, and the plasticizer nonylphenol activate either PXR or both PXR and CAR. |
1(0,0,0,1) | Details |
| 9047321 | Stresser DM, Kupfer D: Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of and mono-O-demethylated methoxychlor. Biochemistry. 1997 Feb 25;36(8):2203-10. |
167(2,2,2,7) | Details |
| 16510540 | Stuchal LD, Kleinow KM, Stegeman JJ, James MO: Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes. Drug Metab Dispos. 2006 Jun;34(6):932-8. Epub 2006 Mar 1. Ketoconazole, and alpha-naphthoflavone all decreased the production of OH-MXC in liver microsomes, whereas alpha-naphthoflavone stimulated HPTE formation, suggesting that CYP1 and CYP3 family isozymes demethylated methoxychlor. |
112(1,2,2,2) | Details |
| 7595932 | Li HC, Dehal SS, Kupfer D: Induction of the hepatic CYP2B and CYP3A enzymes by the proestrogenic pesticide methoxychlor and by DDT in the rat. J Biochem Toxicol. 1995 Feb;10(1):51-61. Both the low (150 mg/kg) and high dose (300 mg/kg) of methoxychlor increased the 6 beta hydroxylation (major product) and 2 beta and 15 beta hydroxylation (minor products) of indicative of increased catalysis by CYP3A. |
87(1,1,2,2) | Details |