| Name | microsomal monooxygenases |
|---|---|
| Synonyms | CPC 8; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; CPC8; CYP2C8; CYPIIC 8; CYPIIC8; Cytochrome P 450 1… |
| Name | methoxychlor |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-methoxybenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2390114 | Bulger WH, Kupfer D: Studies on the formation of methoxychlor-protein adduct in rat and human liver microsomes. Biochem Pharmacol. 1990 Sep 1;40(5):937-45. Previous studies demonstrated that liver microsomal monooxygenases metabolize the pesticide methoxychlor into phenolic estrogenic derivatives. |
81(1,1,1,1) | Details |
| 14985143 | Hu Y, Krausz K, Gelboin HV, Kupfer D: CYP2C subfamily, primarily CYP2C9, catalyses the enantioselective demethylation of the endocrine disruptor pesticide methoxychlor in human liver microsomes: use of inhibitory monoclonal antibodies in P450 identification. Xenobiotica. 2004 Feb;34(2):117-32. There was a substantial difference in the per cent inhibition of demethylation by MAb anti-CYP2C9 and anti-rat CYP2C (MAb inhibiting all human CYP2C forms) and in altering the enantioselectivity, suggesting that demethylation by combined CYP2C8, 2C18 and 2C19 was significant (20-30%). 4. |
1(0,0,0,1) | Details |
| 2573491 | Bulger WH, Kupfer D: Characteristics of monooxygenase-mediated covalent binding of methoxychlor in human and rat liver microsomes. Drug Metab Dispos. 1989 Sep-Oct;17(5):487-94. The characteristics of the activation of methoxychlor by the hepatic microsomal monooxygenases and its covalent binding to microsomal proteins in human and untreated rat were compared. |
81(1,1,1,1) | Details |