| PubMed |
Abstract |
RScore(About this table) |
| 11226075 |
Crellin NK, Kang HG, Swan CL, Chedrese PJ: Inhibition of basal and stimulated progesterone synthesis by dichlorodiphenyldichloroethylene and methoxychlor in a stable pig granulosa cell line. Reproduction. 2001 Mar;121(3):485-92.
The studies of DDE and methoxychlor were conducted in combination with studies of cholera toxin, the protein kinase A activator that stimulates cAMP and progesterone synthesis and gene expression of P450 cholesterol side chain cleavage (P450scc), which converts cholesterol to pregnenolone. |
90(1,1,2,5) |
Details |
| 10684797 |
Akingbemi BT, Ge RS, Klinefelter GR, Gunsalus GL, Hardy MP: A metabolite of methoxychlor, 2,2-bis (p-hydroxyphenyl)-1,1, 1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme. Biol Reprod. 2000 Mar;62(3):571-8.
|
82(1,1,1,2) |
Details |
| 16737795 |
Zachow R, Uzumcu M: The methoxychlor metabolite, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro. Reprod Toxicol. 2006 Nov;22(4):659-65. Epub 2006 Jun 5.
Steady-state levels of the mRNAs encoding steroidogenic acute regulatory protein (StAR), P450 side-chain cleavage (P450scc), 3beta-hydroxysteroid dehydrogenase type 1 (3beta-HSD), and P450 aromatase (P450arom) were examined using real-time PCR. |
2(0,0,0,2) |
Details |
| 18065196 |
Akgul Y, Derk RC, Meighan T, Rao KM, Murono EP: The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells. Reprod Toxicol. 2008 Jan;25(1):67-75. Epub 2007 Oct 25.
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84(1,1,1,4) |
Details |