Protein Information

Name p38
Synonyms AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
19427893 Sorkin LS, Boyle DL, Hammaker D, Herman DS, Vail E, Firestein GS: MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice. Neuroscience. 2009 Aug 18;162(2):462-71. Epub 2009 May 8.

5(0,0,0,5) Details
18033311 Zhou Z, Peng X, Hao S, Fink DJ, Mata M: HSV-mediated transfer of interleukin-10 reduces inflammatory pain through modulation of membrane tumor necrosis factor alpha in spinal cord microglia. Gene Ther. 2008 Feb;15(3):183-90. Epub 2007 Nov 22.


IL-10 reduced the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and decreased the expression of full-length membrane spanning tumor necrosis factor-alpha (mTNFalpha) following lipopolysaccharide stimulation of microglia in vitro.
3(0,0,0,3) Details
18706764 Cao JL, Ruan JP, Ling DY, Guan XH, Bao Q, Yuan Y, Zhang LC, Song XJ, Zeng YM: Activation of peripheral ephrinBs/EphBs signaling induces hyperalgesia through a MAPKs-mediated mechanism in mice. Pain. 2008 Oct 31;139(3):617-31. Epub 2008 Aug 15.


EphrinB1-Fc-induced hyperalgesia is accompanied with the NMDA receptor-mediated increase of expression in peripheral and spinal phosphorylated mitogen-activated protein kinases (phospho-MAPKs) including p-p38, pERK and pJNK, and also is prevented or reversed by the inhibition of peripheral and spinal MAPKs.
2(0,0,0,2) Details