Protein Information

Name c jun
Synonyms AP1; Activator protein 1; JUN; Proto oncogene c jun; Protooncogene c jun; Transcription factor AP 1; V jun avian sarcoma virus 17 oncogene homolog; c Jun…

Compound Information

Name benzalkonium chloride
CAS quaternary ammonium compounds, alkylbenzyldimethyl, chlorides

Reference List

PubMed Abstract RScore(About this table)
12603851 Aiba S, Manome H, Nakagawa S, Mollah ZU, Mizuashi M, Ohtani T, Yoshino Y, Tagami H: p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene. J Invest Dermatol. 2003 Mar;120(3):390-9.

Human monocyte-derived dendritic cells stimulated with 2,4-dinitrochlorobenzene induced the phosphorylation of p38 and stress-activated protein kinase/c-jun N-terminal kinases, whereas NiCl2 induced that of p44/42 extracellular signal-regulated kinases, p38, and stress-activated protein kinase/c-jun N-terminal kinases.
In contrast, primary irritants, e.g., benzalkonium chloride, or sodium lauryl sulfate, did not activate these signal transduction pathways.
1(0,0,0,1) Details
17881916 Okada Y: Effects of topical antiglaucoma medications on corneal epithelium as evaluated by gene expression patterns. Cornea. 2007 Oct;26(9 Suppl 1):S46-54.

PURPOSE: To examine the expression pattern of the stress-related genes c-fos and c-jun, which encode the 2 major components of activator protein (AP)-1, and cyclooxygenase (COX)-2 in rat corneal epithelium treated with topical antiglaucoma medications and benzalkonium chloride (BAK) preservative.
36(0,1,1,6) Details
9211828 Parr EJ, Sharkey KA: Multiple mechanisms contribute to myenteric plexus ablation induced by benzalkonium chloride in the guinea-pig ileum. Cell Tissue Res. 1997 Aug;289(2):253-64.

We examined the effects of this detergent on neurons and glia, including expression of c-Myc, c-Jun, JunB, and c-Fos, and on immunocytes in the guinea-pig ileum.
2(0,0,0,2) Details