| Name | phosphoenolpyruvate carboxykinase |
|---|---|
| Synonyms | PCK 1; PCK1; PEP carboxykinase; PEPCK cytosolic; PEPCK 1; PEPCK C; PEPCKC… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19635791 | Stark R, Pasquel F, Turcu A, Pongratz RL, Roden M, Cline GW, Shulman GI, Kibbey RG: cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion. J Biol Chem. 2009 Sep 25;284(39):26578-90. Epub 2009 Jul 27. |
3(0,0,0,3) | Details |
| 15347677 | Burgess SC, Hausler N, Merritt M, Jeffrey FM, Storey C, Milde A, Koshy S, Lindner J, Magnuson MA, Malloy CR, Sherry AD: Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem. 2004 Nov 19;279(47):48941-9. Epub 2004 Sep 3. |
2(0,0,0,2) | Details |
| 12512946 | Waagepetersen HS, Qu H, Hertz L, Sonnewald U, Schousboe A: Demonstration of recycling in primary cultures of neocortical astrocytes but not in neurons. Neurochem Res. 2002 Nov;27(11):1431-7. This change in the position of the label can only occur by entry of [3-(13) C] into the tricarboxylic acid (TCA) cycle, conversion of labeled alpha-ketoglutarate to or malic enzyme-mediated decarboxylation of to or phosphoenolpyruvate carboxykinase-mediated conversion of to and subsequent hydrolysis of the latter to and introduction of the labeled into the TCA cycle, i.e., after exit of the carbon skeleton of from the TCA cycle followed by re-entry of the same molecules via |
1(0,0,0,1) | Details |
| 12948633 | Gerstmeir R, Wendisch VF, Schnicke S, Ruan H, Farwick M, Reinscheid D, Eikmanns BJ: metabolism and its regulation in Corynebacterium glutamicum. J Biotechnol. 2003 Sep 4;104(1-3):99-122. These genes, thus also belonging to the stimulon of C. glutamicum, include genes coding for TCA cycle enzymes (e.g. aconitase and succinate dehydrogenase), for gluconeogenesis (phosphoenolpyruvate carboxykinase), for glycolysis (pyruvate dehydrogenase E1) and genes coding for proteins with hitherto unknown function. |
1(0,0,0,1) | Details |
| 15797985 | Burgess SC, Jeffrey FM, Storey C, Milde A, Hausler N, Merritt ME, Mulder H, Holm C, Sherry AD, Malloy CR: Effect of murine strain on metabolic pathways of production after brief or prolonged fasting. Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E53-61. Epub 2005 Mar 29. FVB mice also had a 30% higher in vivo phosphoenolpyruvate carboxykinase flux and total production from the level of the TCA cycle compared with B6 and 129 strains, while total body production in the 129 strain was approximately 30% lower than in either FVB or B6 mice. |
1(0,0,0,1) | Details |
| 20167786 | Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL: Regulation of cellular metabolism by protein acetylation. . Science. 2010 Feb 19;327(5968):1000-4. Acetylation activated enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase in fatty acid oxidation and malate dehydrogenase in the TCA cycle, inhibited argininosuccinate lyase in the urea cycle, and destabilized phosphoenolpyruvate carboxykinase in gluconeogenesis. |
1(0,0,0,1) | Details |
| 12855734 | Liu K, Yu J, Russell DG: pckA-deficient Mycobacterium bovis BCG shows attenuated virulence in mice and in macrophages. Microbiology. 2003 Jul;149(Pt 7):1829-35. Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) to form phosphoenolpyruvate (PEP). |
1(0,0,0,1) | Details |
| 15562253 | Jin ES, Burgess SC, Merritt ME, Sherry AD, Malloy CR: Differing mechanisms of hepatic overproduction in -treated rats vs. Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E654-62. Epub 2004 Nov 23. In T3-treated rats, the hepatic content and hence the contribution of glycogenolysis to production was essentially zero; in this case, excess production was due to a dramatic increase in gluconeogenesis from TCA cycle intermediates. 13C NMR analysis also revealed increased phosphoenolpyruvate carboxykinase flux (4x), increased cycling flux (4x), and increased TCA flux (5x) in T3-treated animals. |
1(0,0,0,1) | Details |
| 17403375 | Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA: Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab. 2007 Apr;5(4):313-20. Expression of phosphoenolpyruvate carboxykinase (PEPCK), commonly considered the control point for liver gluconeogenesis, is normally regulated by circulating hormones to match systemic demand. |
1(0,0,0,1) | Details |
| 17339216 | Hynes MJ, Szewczyk E, Murray SL, Suzuki Y, Davis MA, Sealy-Lewis HM: Transcriptional control of gluconeogenesis in Aspergillus nidulans. Genetics. 2007 May;176(1):139-50. Epub 2007 Mar 4. We have cloned the acuG gene encoding -1,6 bisphosphatase and found that expression of this gene is regulated by carbon catabolite repression as well as by induction by a TCA cycle intermediate similar to the induction of the previously studied acuF gene encoding phosphoenolpyruvate carboxykinase. |
1(0,0,0,1) | Details |
| 12526195 | Karavaiko GI, Zakharchuk LM, Bogdanova TI, Egorova MA, Tsaplina IA, Krasil'nikova EN: [The enzyme of carbon metabolism in the thermotolerant sulfobacillus strain K1]. Mikrobiologiia. 2002 Nov-Dec;71(6):755-61. The activities of pyruvate carboxylase, phosphoenolpyruvate carboxylase, phosphoenolpyruvate carboxykinase, and carboxytransphosphorylase decreased with the increasing content of CO2 in the medium. |
1(0,0,0,1) | Details |
| 15491857 | Zamboni N, Maaheimo H, Szyperski T, Hohmann HP, Sauer U: The phosphoenolpyruvate carboxykinase also catalyzes C3 carboxylation at the interface of glycolysis and the TCA cycle of Bacillus subtilis. Metab Eng. 2004 Oct;6(4):277-84. |
1(0,0,0,1) | Details |