TCA

Identification (Source:EPA,EU)

ID 955
Name TCA
CAS 76-03-9
IUPAC trichloroacetic acid
Inchi InChI=1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
CIPAC
EPA Code
Formula C2HCl3O2
SMILES ClC(C(=O)O[H])(Cl)Cl
Status Not Approved

Classification

Mode of Action
Pesticide Type
Chemical Group
Classification halogenated aliphatic herbicides

Properties (Source:PubChem)

Molecular Weight 163.38713
Physical State
AlogP 1.473
H-Bond Donor 1
H-Bond Acceptor 2
Surface Area 138.03
Polar Surface Area 37.29

Structure



ChemMapper Search Option (Docunmentation of ChemMapper)

3D similarity method

2D similarity method

Compound Database



Bioactivity Database

KEGG (5,928)

PDB (7,072)


Similarity Threshold

Related targets

Target Name RScore (About this table)
HDAC 207(2,2,9,12) Details
epidermal growth factor receptor 179(2,2,2,19) Details
caspase (protein family or complex) 163(2,2,2,3) Details
bcl 2 88(1,1,1,8) Details
GTPase 83(1,1,1,3) Details
caspase 8 82(1,1,1,2) Details
ATPase 62(0,1,1,32) Details
cytochrome P450 arachidonic acid epoxygenases 56(0,1,4,11) Details
carbonic anhydrase 49(0,1,1,19) Details
monoamine oxidase 43(0,1,1,13) Details
cytochrome P450 (protein family or complex) 43(0,1,2,8) Details
ERK1 39(0,1,1,9) Details
metalloproteinases 36(0,1,1,6) Details
glutathione S transferase 36(0,1,1,6) Details
nNOS 35(0,1,1,5) Details
PARP 34(0,1,1,4) Details
methylmalonyl CoA mutase 31(0,1,1,1) Details
P27 31(0,1,1,1) Details
methionine synthase 31(0,1,1,1) Details
albumin 115(0,0,13,50) Details
aconitase 89(0,0,0,89) Details
isocitrate dehydrogenase 67(0,0,0,67) Details
succinate dehydrogenase (protein family or complex) 64(0,0,0,64) Details
pyruvate dehydrogenase (protein family or complex) 58(0,0,0,58) Details
citrate synthase 56(0,0,0,56) Details
malate dehydrogenase 50(0,0,0,50) Details
alpha ketoglutarate dehydrogenase 48(0,0,0,48) Details
parathyroid hormone 45(0,0,6,15) Details
fumarate hydratase 41(0,0,0,41) Details
glycolytic enzyme 41(0,0,0,41) Details
pyruvate carboxylase 39(0,0,0,39) Details
chemokines 35(0,0,0,35) Details
peroxisome proliferator activated receptor alpha 32(0,0,0,32) Details
PEPCK 27(0,0,0,27) Details
casein 26(0,0,3,11) Details
superoxide dismutase 25(0,0,0,25) Details
lactate dehydrogenase (protein family or complex) 25(0,0,0,25) Details
HDAC1 24(0,0,4,4) Details
HSCR 23(0,0,0,23) Details
endostatin 23(0,0,3,8) Details
glucose 6 phosphate dehydrogenase 20(0,0,0,20) Details
apical sodium dependent bile acid transporter 20(0,0,0,20) Details
leptin 19(0,0,0,19) Details
GABA transaminase 19(0,0,0,19) Details
brains 19(0,0,0,19) Details
activator protein 1 19(0,0,0,19) Details
CD4 19(0,0,0,19) Details
histone deacetylase (protein family or complex) 18(0,0,2,8) Details
extracellular matrix metalloproteinase inducer 18(0,0,2,8) Details
cyclin D1 17(0,0,1,12) Details
complex I 17(0,0,0,17) Details
transferase 17(0,0,0,17) Details
aspartate aminotransferase 16(0,0,0,16) Details
SDHB 16(0,0,0,16) Details
phosphoenolpyruvate carboxykinase 15(0,0,0,15) Details
myoglobin 15(0,0,0,15) Details
hemoglobin (protein family or complex) 15(0,0,0,15) Details
insulin like growth factor binding protein 3 14(0,0,0,14) Details
protein is 14(0,0,0,14) Details
alkaline phosphatase 14(0,0,1,9) Details
HIF 1alpha 13(0,0,0,13) Details
transketolase 13(0,0,0,13) Details
catalase 13(0,0,0,13) Details
cytochrome c 13(0,0,0,13) Details
CYP2E1 13(0,0,0,13) Details
serotonin transporter 13(0,0,0,13) Details
P glycoprotein 12(0,0,0,12) Details
interleukin 1beta 12(0,0,0,12) Details
GLUT1 12(0,0,0,12) Details
vascular endothelial growth factor 12(0,0,0,12) Details
Cytochrome c oxidase (protein family or complex) 12(0,0,0,12) Details
AP 1 (protein family or complex) 12(0,0,0,12) Details
CYP7B1 12(0,0,0,12) Details
PDK1 11(0,0,0,11) Details
AD9 11(0,0,0,11) Details
PPARdelta 11(0,0,0,11) Details
IL 18 11(0,0,0,11) Details
alanine aminotransferase 11(0,0,0,11) Details
CYP7A1 11(0,0,0,11) Details
mitogen activated protein kinase (protein family or complex) 11(0,0,0,11) Details
glutamine synthase 11(0,0,0,11) Details
5 HT1A 10(0,0,0,10) Details
OATP1B1 10(0,0,0,10) Details
KRAS 10(0,0,1,5) Details
RNase 10(0,0,1,5) Details
tumor necrosis factor alpha 10(0,0,0,10) Details
ERCC1 10(0,0,0,10) Details
CD40 10(0,0,0,10) Details
bile salt export pump 10(0,0,0,10) Details
NMDA receptor (protein family or complex) 10(0,0,0,10) Details
sodium channel (protein family or complex) 10(0,0,0,10) Details
Connexin 43 10(0,0,0,10) Details
AP 2 10(0,0,0,10) Details
brain derived neurotrophic factor 9(0,0,0,9) Details
calmodulin 9(0,0,0,9) Details
glutaminase 9(0,0,0,9) Details
CYP2D6 9(0,0,0,9) Details
protein as 9(0,0,0,9) Details
c Myc 9(0,0,0,9) Details
monoamine transporter 9(0,0,0,9) Details
calcineurin (protein family or complex) 9(0,0,0,9) Details
S12 9(0,0,0,9) Details
phosphoglycerate kinase 9(0,0,1,4) Details
Ghrelin 9(0,0,0,9) Details
enolase 9(0,0,0,9) Details
citrate lyase (protein family or complex) 9(0,0,0,9) Details
TCA 3 9(0,0,0,9) Details
RORalpha 9(0,0,0,9) Details
acetyl CoA synthetase 9(0,0,0,9) Details
methylmalonate semialdehyde dehydrogenase 9(0,0,0,9) Details
caspase 3 8(0,0,0,8) Details
P protein 8(0,0,1,3) Details
protein kinase C (protein family or complex) 8(0,0,0,8) Details
ET A 8(0,0,0,8) Details
alcohol dehydrogenase (protein family or complex) 8(0,0,0,8) Details
fibronectin 8(0,0,0,8) Details
MR 1 8(0,0,0,8) Details
thrombin 8(0,0,0,8) Details
peroxisome proliferator activated receptor gamma 8(0,0,0,8) Details
PI3K 8(0,0,0,8) Details
Ghrelin receptor 8(0,0,1,3) Details
miR 21 8(0,0,1,3) Details
miR 214 8(0,0,1,3) Details
Kir4.1 8(0,0,0,8) Details
TP53BP1 8(0,0,0,8) Details
topoisomerase II beta 8(0,0,1,3) Details
muscles 8(0,0,0,8) Details
TP53 7(0,0,0,7) Details
SERCA1 7(0,0,0,7) Details
glucose 6 phosphatase 7(0,0,0,7) Details
mGluR5 7(0,0,0,7) Details
succinic semialdehyde dehydrogenase 7(0,0,0,7) Details
NADH dehydrogenase 7(0,0,0,7) Details
ferritin (protein family or complex) 7(0,0,0,7) Details
proliferating cell nuclear antigen 7(0,0,1,2) Details
osteocalcin 7(0,0,1,2) Details
retinoid X receptor alpha 7(0,0,0,7) Details
IP 10 7(0,0,0,7) Details
B12 7(0,0,0,7) Details
CCR8 7(0,0,0,7) Details
SLURP 1 7(0,0,0,7) Details
cytosolic malate dehydrogenase 7(0,0,0,7) Details
Fetuin A 7(0,0,1,2) Details
BRCA1 7(0,0,0,7) Details
CRHR1 7(0,0,0,7) Details
peripherin 7(0,0,0,7) Details
early growth response 1 7(0,0,0,7) Details
AOX1 7(0,0,0,7) Details
Pax6 7(0,0,0,7) Details
SDHC 7(0,0,0,7) Details
TFF3 7(0,0,0,7) Details
GluD 1 7(0,0,0,7) Details
CYP3A4 7(0,0,0,7) Details
glutathione reductase 6(0,0,0,6) Details
RIP140 6(0,0,0,6) Details
G protein 6(0,0,0,6) Details
Cl 2 6(0,0,0,6) Details
monoamine oxidase A 6(0,0,0,6) Details
HCl 1 6(0,0,1,1) Details
P30 6(0,0,0,6) Details
CD8 6(0,0,0,6) Details
IL 10 6(0,0,0,6) Details
ATPases 6(0,0,0,6) Details
apolipoprotein E 6(0,0,0,6) Details
phosphofructokinase 6(0,0,0,6) Details
multidrug resistance associated protein 2 6(0,0,0,6) Details
uncoupling protein 2 6(0,0,0,6) Details
SDHD 6(0,0,0,6) Details
osteoprotegerin 6(0,0,1,1) Details
ERp57 6(0,0,0,6) Details
CNT2 6(0,0,0,6) Details
IGFBP 6 6(0,0,0,6) Details
gga 3 6(0,0,1,1) Details
SPAP 6(0,0,1,1) Details
ING1 6(0,0,0,6) Details
ERRalpha 6(0,0,0,6) Details
TCTA 6(0,0,1,1) Details
Tapasin 6(0,0,0,6) Details
thioredoxin interacting protein 6(0,0,0,6) Details
C18 6(0,0,0,6) Details
immunoglobulin (protein family or complex) 5(0,0,0,5) Details
ECRG2 5(0,0,0,5) Details
p38 5(0,0,0,5) Details
P10 5(0,0,0,5) Details
ubiquitin 5(0,0,0,5) Details
glyceraldehyde 3 phosphate dehydrogenase 5(0,0,0,5) Details
PC3 5(0,0,0,5) Details
CFTR 5(0,0,0,5) Details
BRAF 5(0,0,0,5) Details
FOXO3a 5(0,0,0,5) Details
RANTES 5(0,0,0,5) Details
Urokinase type plasminogen activator 5(0,0,0,5) Details
chemokine receptors (protein family or complex) 5(0,0,0,5) Details
HERG 5(0,0,0,5) Details
AAP1 5(0,0,0,5) Details
TFF2 5(0,0,0,5) Details
P cadherin 5(0,0,0,5) Details
ARL1 5(0,0,0,5) Details
MondoA 5(0,0,0,5) Details
Gfi 1 5(0,0,0,5) Details
Foxo1a 5(0,0,0,5) Details
TRMA 5(0,0,0,5) Details
Avpr1b 5(0,0,0,5) Details
vascular endothelial growth factor C 5(0,0,0,5) Details
Netrin G1 5(0,0,0,5) Details
long chain acyl CoA dehydrogenase 5(0,0,0,5) Details
collectrin 5(0,0,0,5) Details
macrophage inflammatory protein 1 alpha 5(0,0,0,5) Details
isocitrate dehydrogenase 1 5(0,0,0,5) Details
c kit 5(0,0,0,5) Details
calcium channel (protein family or complex) 4(0,0,0,4) Details
receptor tyrosine kinases 4(0,0,0,4) Details
cathepsin D 4(0,0,0,4) Details
beta glucuronidase 4(0,0,0,4) Details
metallothionein (protein family or complex) 4(0,0,0,4) Details
prion protein 4(0,0,0,4) Details
angiotensin II 4(0,0,0,4) Details
IL 12 (protein family or complex) 4(0,0,0,4) Details
P14 4(0,0,0,4) Details
demethylase 4(0,0,0,4) Details
aldehyde dehydrogenase (protein family or complex) 4(0,0,0,4) Details
TFF1 4(0,0,0,4) Details
erythropoietin 4(0,0,0,4) Details
statins 4(0,0,0,4) Details
DCIP 4(0,0,0,4) Details
plasmin 4(0,0,0,4) Details
PARP 1 4(0,0,0,4) Details
adiponectin 4(0,0,0,4) Details
fatty acid synthase 4(0,0,0,4) Details
glycogen synthase 4(0,0,0,4) Details
caveolin 1 4(0,0,0,4) Details
CD16 4(0,0,0,4) Details
TGFbeta 4(0,0,0,4) Details
CART 4(0,0,0,4) Details
6 phosphogluconate dehydrogenase 4(0,0,0,4) Details
AC1 4(0,0,0,4) Details
ATH1 4(0,0,0,4) Details
ICER 4(0,0,0,4) Details
CXCR2 4(0,0,0,4) Details
SUCLA2 4(0,0,0,4) Details
phosphoglucose isomerase 4(0,0,0,4) Details
CMT1 4(0,0,0,4) Details
P44 4(0,0,0,4) Details
growth hormone receptor 4(0,0,0,4) Details
neurotrophic factors 4(0,0,0,4) Details
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ID Name Type

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