| Name | PEPCK |
|---|---|
| Synonyms | Full length cDNA clone CS0DC022YA24 of Neuroblastoma of Homo sapiens; PEP carboxykinase; Phosphoenolpyruvate carboxylase; Mitochondrial phosphoenolpyruvate carboxykinase 2; PCK 2; PCK2; PCK2 protein; PEPCK… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15347677 | Burgess SC, Hausler N, Merritt M, Jeffrey FM, Storey C, Milde A, Koshy S, Lindner J, Magnuson MA, Malloy CR, Sherry AD: Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem. 2004 Nov 19;279(47):48941-9. Epub 2004 Sep 3. Liver-specific phosphoenolpyruvate carboxykinase (PEPCK) null mice, when fasted, maintain normal whole body kinetics but develop dramatic hepatic steatosis. |
5(0,0,0,5) | Details |
| 12855734 | Liu K, Yu J, Russell DG: pckA-deficient Mycobacterium bovis BCG shows attenuated virulence in mice and in macrophages. Microbiology. 2003 Jul;149(Pt 7):1829-35. Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) to form phosphoenolpyruvate (PEP). |
3(0,0,0,3) | Details |
| 20305288 | Cao R, Cronk ZX, Zha W, Sun L, Wang X, Fang Y, Studer E, Zhou H, Pandak WM, Dent P, Gil G, Hylemon PB: Bile acids regulate hepatic gluconeogenic genes and FXR via G-alpha-i protein coupled receptor (s) and the AKT pathway. J Lipid Res. 2010 Mar 20. In the current study, the chronic bile fistula (CBF) rat model and primary rat hepatocytes (PRH) were used to study the regulation of gluconeogenic genes (PEPCK and G-6-Pase) and the gene encoding short heterodimeric partner (SHP) by taurocholate (TCA). |
2(0,0,0,2) | Details |
| 17114268 | Tang YJ, Meadows AL, Kirby J, Keasling JD: Anaerobic central metabolic pathways in Shewanella oneidensis MR-1 reinterpreted in the light of isotopic metabolite labeling. J Bacteriol. 2007 Feb;189(3):894-901. Epub 2006 Nov 17. The labeling data also suggest significant activity in the anapleurotic (malic enzyme and phosphoenolpyruvate carboxylase) reactions. |
1(0,0,0,1) | Details |
| 18956755 | Huang J, Xu Q, Wen T, Chen N: [Metabolic flux analysis of biosynthesis strain under diverse dissolved conditions]. Wei Sheng Wu Xue Bao. 2008 Aug 4;48(8):1056-60. CONCLUSION: Compared to the optimal metabolic flux with a carbon conversion rate of 88.23%, glucose-6-phosphate isomerase should be activated by genetic manipulation and fermentation control in order to elevate the HMP pathway flux, and flux towards amino acids family could be enhanced by increasing phosphoenolpyruvate carboxylase reaction rate. |
1(0,0,0,1) | Details |
| 18339202 | Becker J, Klopprogge C, Wittmann C: Metabolic responses to kinase deletion in producing Corynebacterium glutamicum. Microb Cell Fact. 2008 Mar 13;7:8. In kinase deficient strains the required equimolar ratio of the two precursors and can be achieved through concerted action of the phosphotransferase system (PTS) and phosphoenolpyruvate carboxylase (PEPC), whereby a reduced amount of carbon may be lost as CO2 due to reduced flux into the tricarboxylic acid (TCA) cycle. |
1(0,0,0,1) | Details |
| 12526195 | Karavaiko GI, Zakharchuk LM, Bogdanova TI, Egorova MA, Tsaplina IA, Krasil'nikova EN: [The enzyme of carbon metabolism in the thermotolerant sulfobacillus strain K1]. Mikrobiologiia. 2002 Nov-Dec;71(6):755-61. The activities of pyruvate carboxylase, phosphoenolpyruvate carboxylase, phosphoenolpyruvate carboxykinase, and carboxytransphosphorylase decreased with the increasing content of CO2 in the medium. |
1(0,0,0,1) | Details |
| 15051530 | Jin ES, Jones JG, Merritt M, Burgess SC, Malloy CR, Sherry AD: production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single derivative. Anal Biochem. 2004 Apr 15;327(2):149-55. Plasma was converted to monoacetone (MAG), and a single (2) H and (13) C NMR spectrum of MAG provided the following metabolic data (all in units of micromol/kg/min; n = 6): endogenous production (40.4+/-2.9), gluconeogenesis from (11.5+/-3.5), gluconeogenesis from the TCA cycle (67.3+/-5.6), glycogenolysis (1.0+/-0.8), cycling (154.4+/-43.4), PEPCK flux (221.7+/-47.6), and TCA cycle flux (49.1+/-16.8). |
1(0,0,0,1) | Details |
| 19635791 | Stark R, Pasquel F, Turcu A, Pongratz RL, Roden M, Cline GW, Shulman GI, Kibbey RG: cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion. J Biol Chem. 2009 Sep 25;284(39):26578-90. Epub 2009 Jul 27. Here we have investigated whether the mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) is the GTPase linking hydrolysis of mtGTP made by synthetase (SCS-GTP) to an anaplerotic pathway producing phosphoenolpyruvate (PEP). |
7(0,0,0,7) | Details |
| 17403375 | Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA: Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab. 2007 Apr;5(4):313-20. Expression of phosphoenolpyruvate carboxykinase (PEPCK), commonly considered the control point for liver gluconeogenesis, is normally regulated by circulating hormones to match systemic demand. |
5(0,0,0,5) | Details |