Protein Information

Name G protein
Synonyms G gamma I; Guanine nucleotide binding protein 2; G protein; GNG 2; GNG2; GNGT 2; GNGT2; Guanine nucleotide binding protein gamma 2…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
15880757 Han DW, Watson RD: Trimeric G proteins in crustacean (Callinectes sapidus) Y-organs: occurrence and functional link to protein synthesis. J Exp Zool A Comp Exp Biol. 2005 Jun 1;303(6):441-7.

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16035959 Rossi DV, Valdez M, Gould GG, Hensler JG: Chronic administration of venlafaxine fails to attenuate 5-HT1A receptor function at the level of receptor-G protein interaction. Int J Neuropsychopharmacol. 2006 Aug;9(4):393-406. Epub 2005 Jul 22.


We evaluated, using quantitative autoradiography, the effect of these antidepressant treatments on [35S] GTPgammaS binding stimulated by the 5-HT1A receptor agonist 8-OH-DPAT, a measure of the capacity of 5-HT1A receptors to activate G proteins.
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12422559 Bourin M, David DJ, Jolliet P, Gardier A: [Mechanism of action of antidepressants and therapeutic perspectives] . Therapie. 2002 Jul-Aug;57(4):385-96.


Indirect activation of neurotransmitter receptors by antidepressants may also lead, via increases in endogenous levels of serotonin in synapses in specific brain regions, to activation of various G proteins coupled to a receptor, signal of transduction, transcription factors and neurotrophic factors such as brain-derived neurotrophic factor (BDNF).
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