Protein Information

Name transferase
Synonyms 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
19340598 Kumar V, Sahu NP, Pal AK, Kumar S, Sinha AK, Ranjan J, Baruah K: Modulation of key enzymes of glycolysis, gluconeogenesis, amino acid catabolism, and TCA cycle of the tropical freshwater fish Labeo rohita fed gelatinized and non-gelatinized starch diet. Fish Physiol Biochem. 2009 Apr 2.


A 60-day experiment was conducted to study the effect of dietary gelatinized (G) and non-gelatinized (NG) starch on the key metabolic enzymes of glycolysis (hexokinase, glucokinase, pyruvate kinase, and lactate dehydrogenase), gluconeogenesis (glucose-6 phosphatase and fructose-1,6 bisphosphatase), protein metabolism (aspartate amino transferase and alanine amino transferase), and TCA cycle (malate dehydrogenase) in Labeo rohita juveniles.
3(0,0,0,3) Details
17726146 Jucker BM, Yang D, Casey WM, Olzinski AR, Williams C, Lenhard SC, Legos JJ, Hawk CT, Sarkar SK, Newsholme SJ: Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1256-64. Epub 2007 Aug 28.

Soleus muscle GLUT4 expression was decreased by twofold, whereas pyruvate dehydrogenase kinase 4, carnitine palmitoyl transferase 1a, and uncoupling protein 2 and 3 expression was increased by two- to threefold at the high dose (P < 0.05).
In separate experiments where mitochondrial coupling was assessed in vivo (day 7), (31) P-MRS was used to measure hindlimb ATP synthesis and (13) C-MRS was used to measure the hindlimb tricarboxylic acid cycle flux (V (tca)).
1(0,0,0,1) Details
16249254 Wang C, Kerckhofs K, Van de Casteele M, Smolders I, Pipeleers D, Ling Z: Glucose inhibits GABA release by pancreatic beta-cells through an increase in GABA shunt activity. Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E494-9. Epub 2005 Oct 25.


Net GABA production is the result of GABA formation through glutamate decarboxylase (GAD) and GABA catabolism involving a GABA-transferase (GABA-T)-mediated shunt to the TCA cycle.
1(0,0,0,1) Details
16857877 Walsh PJ, Kajimura M, Mommsen TP, Wood CM: Metabolic organization and effects of feeding on enzyme activities of the dogfish shark (Squalus acanthias) rectal gland. J Exp Biol. 2006 Aug;209(Pt 15):2929-38.


Several enzymes showed a large increase in activity post-feeding, including beta-hydroxybutyrate dehydrogenase in rectal gland and liver, and in rectal gland, isocitrate dehydrogenase, citrate synthase, lactate dehydrogenase, aspartate amino transferase, alanine amino transferase, glutamine synthetase and Na (+)/K (+) ATPase.
1(0,0,0,1) Details
19162097 Veit A, Rittmann D, Georgi T, Youn JW, Eikmanns BJ, Wendisch VF: Pathway identification combining metabolic flux and functional genomics analyses: acetate and propionate activation by Corynebacterium glutamicum. J Biotechnol. 2009 Mar 10;140(1-2):75-83. Epub 2008 Dec 27.


DNA microarray experiments identified cg2840 as a constitutively and highly expressed gene putatively encoding a CoA transferase.
3(0,0,0,3) Details
19861411 Jensen PR, Peitersen T, Karlsson M, In 't Zandt R, Gisselsson A, Hansson G, Meier S, Lerche MH: Tissue-specific short chain fatty acid metabolism and slow metabolic recovery after ischemia from hyperpolarized NMR in vivo. J Biol Chem. 2009 Dec 25;284(52):36077-82. Epub 2009 Oct 27.


This is achieved by assaying acetyl-CoA synthetase and acetyl-carnitine transferase catalyzed transformations in vivo.
2(0,0,0,2) Details
19809498 Singh R, Lemire J, Mailloux RJ, Chenier D, Hamel R, Appanna VD: An ATP and oxalate generating variant tricarboxylic acid cycle counters aluminum toxicity in Pseudomonas fluorescens. PLoS One. 2009 Oct 7;4(10):e7344.


The increased activity of succinyl-CoA synthetase (SCS) and oxalate CoA-transferase (OCT) in the Al-stressed cells afforded an effective route to ATP synthesis from oxalyl-CoA via substrate level phosphorylation.
1(0,0,0,1) Details
20337899 Phan TC, Ooi J, Goonewardene MS: A novel molecule, SLURP-1, enhances the survival of periodontal ligament fibroblasts. J Periodontal Res. 2010 Mar 9.


In addition, the apoptotic effect was examined using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay.
1(0,0,0,1) Details
16478453 Kurbatov L, Albrecht D, Herrmann H, Petruschka L: Analysis of the proteome of Pseudomonas putida KT2440 grown on different sources of carbon and energy. Environ Microbiol. 2006 Mar;8(3):466-78.


Whereas the synthesis of Phl-proteins (subunits of the phenolhydroxylase) only decreased slowly, was the translation of the Cat-proteins (catechol 1,2-dioxygenase, cis,cis-muconate cycloisomerase and muconolactone isomerase) repressed immediately and the synthesis of the Pca-proteins (beta-ketoadipate enolactone hydrolase, beta-ketoadipate succinyl-CoA transferase and beta-ketoadipyl CoA thiolase) remained unaffected.
1(0,0,0,1) Details
19530707 Kim DH, Choe YS, Choi JY, Choi Y, Lee KH, Kim BT: 17-[4-(2-[18F] fluoroethyl)-1H-1,2,3-triazol-1-yl]-6-thia-heptadecanoic acid: a potential radiotracer for the evaluation of myocardial fatty acid metabolism. Bioconjug Chem. 2009 Jun;20(6):1139-45.


Pretreatment with etomoxir, a carnitine palmitoyl transferase (CPT) I inhibitor, reduced myocardial radioactivity uptake at 30 min postinjection by 53%, suggesting that [(18) F] 1 was transported into the mitochondria.
1(0,0,0,1) Details
15989231 Song SS, Ma H, Gao ZX, Jia ZH, Zhang X: [Construction of recombinant Escherichia coli strains producing poly (4-hydroxybutyric acid) homopolyester from glucose]. Wei Sheng Wu Xue Bao. 2005 Jun;45(3):382-6.


A glutamate: succinate semialdehyde transaminase gene from Escherichia coli, a glutamate decarboxylase gene from E. coli, and a 4-hydroxybutyrate dehydrogenase gene from Ralstonia eutropha were cloned by PCR and assembled onto the plasmid pKSSE5.3 which haboured the PHA synthase gene from Ralstonia eutropha and 4-hydroxybutyrate: CoA transferase from Clostridium kluyveri.
1(0,0,0,1) Details
15940471 Anand SS, Mumtaz MM, Mehendale HM: Dose-dependent liver regeneration in chloroform, trichloroethylene and allyl alcohol ternary mixture hepatotoxicity in rats. Arch Toxicol. 2005 Nov;79(11):671-82. Epub 2005 Jun 7.


Liver injury was assessed by plasma alanine amino transferase (ALT) activity and liver tissue repair was measured by (3) H-thymidine incorporation into hepatonuclear DNA.
1(0,0,0,1) Details