| Name | alpha ketoglutarate dehydrogenase |
|---|---|
| Synonyms | 2 ketoglutarate dehydrogenase deficiency; 2 oxoglutarate dehydrogenase E1 component; AKGDH; Alpha KGD deficiency; Alpha ketoglutarate dehydrogenase; Alpha ketoglutarate dehydrogenase deficiency; E1K; OGDC… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12119542 | Madej M, Lundh T, Lindberg JE: Activity of enzymes involved in energy production in the small intestine during suckling-weaning transition of pigs. Biol Neonate. 2002;82(1):53-60. The activity of citrate synthase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, dehydrogenase, alanine aminotransferase and aspartate aminotransferase was determined in the small intestine epithelium of piglets during suckling-weaning transition. |
3(0,0,0,3) | Details |
| 20222442 | Zhang D, Liu L, Du G, Chen J: [Physiological function of alpha-ketoglutarate dehydrogenase complex in Torulopsis glabrata]. Wei Sheng Wu Xue Bao. 2009 Dec 4;49(12):1584-9. |
3(0,0,0,3) | Details |
| 18206986 | Shi Q, Xu H, Kleinman WA, Gibson GE: Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease. Biochim Biophys Acta. 2008 Apr;1782(4):229-38. Epub 2007 Dec 31. |
2(0,0,0,2) | Details |
| 17273855 | Veit A, Polen T, Wendisch VF: Global gene expression analysis of overflow metabolism in Escherichia coli and reduction of aerobic formation. Appl Microbiol Biotechnol. 2007 Feb;74(2):406-21. Epub 2006 Nov 25. A correlation analysis identified that expression of ten genes (sdhCDAB, sucB, sucC, acnB, lpdA, fumC and mdh) encoding the TCA cycle enzymes succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, synthetase, aconitase, fumarase and malate dehydrogenase, respectively, and of the acs-yjcH-actP operon for utilization correlated negatively with formation. |
2(0,0,0,2) | Details |
| 12527416 | Huang HM, Zhang H, Xu H, Gibson GE: Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular regulation. Biochim Biophys Acta. 2003 Jan 20;1637(1):119-26. |
2(0,0,0,2) | Details |
| 12631716 | McCammon MT, Epstein CB, Przybyla-Zawislak B, McAlister-Henn L, Butow RA: Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes. Mol Biol Cell. 2003 Mar;14(3):958-72. Another set of genes displayed a pairwise, alternating pattern of expression in response to contiguous TCA cycle enzyme defects: expression was elevated in aconitase and isocitrate dehydrogenase mutants, diminished in alpha-ketoglutarate dehydrogenase and ligase mutants, elevated again in succinate dehydrogenase and fumarase mutants, and diminished again in malate dehydrogenase and citrate synthase mutants. |
2(0,0,0,2) | Details |
| 16416424 | Santos SS, Gibson GE, Cooper AJ, Denton TT, Thompson CM, Bunik VI, Alves PM, Sonnewald U: Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C] and [U-13C] glutamate metabolism in cerebellar granule neurons. J Neurosci Res. 2006 Feb 15;83(3):450-8. |
2(0,0,0,2) | Details |
| 17346854 | Johansen ML, Bak LK, Schousboe A, Iversen P, Sorensen M, Keiding S, Vilstrup H, Gjedde A, Ott P, Waagepetersen HS: The metabolic role of in detoxification of in cultured mouse neurons and astrocytes. Neurochem Int. 2007 Jun;50(7-8):1042-51. Epub 2007 Feb 6. oxidation including tricarboxylic acid (TCA) cycle metabolism has been suggested to be inhibited by hyperammonemia at the and alpha-ketoglutarate dehydrogenase steps. |
2(0,0,0,2) | Details |
| 16413626 | Mohankumar K, Ramasamy P: Activities of membrane bound phosphatases, transaminases and mitochondrial enzymes in white spot syndrome virus infected tissues of Fenneropenaeus indicus. Virus Res. 2006 Jun;118(1-2):130-5. Epub 2006 Jan 18. The activities of membrane bound phosphatases (Na (+) K (+) ATPase, Ca (2+) ATPase, Mg (2+) ATPase and Total ATPase), transaminases transaminase (ALT) and transaminase (AST)) and mitochondrial enzymes (isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), alpha-ketoglutarate dehydrogenase (KGDH), NADH dehydrogenase, cytochrome C oxidase) in WSSV-infected tissues (hemolymph, hepatopancreas, gills and muscle) of Fenneropenaeus indicus were determined at intervals after WSSV infection (0, 24, 48, 72 and after 72 h (moribund)). |
1(0,0,0,1) | Details |
| 19343341 | Imperlini E, Bianco C, Lonardo E, Camerini S, Cermola M, Moschetti G, Defez R: Effects of on Sinorhizobium meliloti survival and on symbiotic fixation and stem dry weight production. Appl Microbiol Biotechnol. 2009 Jun;83(4):727-38. Epub 2009 Apr 3. We assayed the activity of tricarboxylic acid cycle (TCA) key enzymes and found that activity of citrate synthase and alpha-ketoglutarate dehydrogenase were increased in both 1021+ and RD64 as compared to the wild-type strain. |
1(0,0,0,1) | Details |
| 12949191 | Camarasa C, Grivet JP, Dequin S: Investigation by 13C-NMR and tricarboxylic acid (TCA) deletion mutant analysis of pathways for formation in Saccharomyces cerevisiae during anaerobic fermentation. Microbiology. 2003 Sep;149(Pt 9):2669-78. Consistent with this finding, a kgd1 mutant displayed lower levels of production on than on other sources, and higher levels of oxoglutarate dehydrogenase activity were observed on |
1(0,0,0,1) | Details |
| 12868651 | Herbert M, Kraiss A, Hilpert AK, Schlor S, Reidl J: Aerobic growth deficient Haemophilus influenzae mutants are non-virulent: implications on metabolism. Int J Med Microbiol. 2003 Jun;293(2-3):145-52. Since LpdA is a functional subunit of both pyruvate dehydrogenase (aceEF) and alpha-ketoglutarate dehydrogenase (sucAB) the phenotype of the lpdA mutant was further explored by creating separate knockout mutants in the sucAB and aceEF loci. |
1(0,0,0,1) | Details |
| 17574827 | Buddhan S, Sivakumar R, Dhandapani N, Ganesan B, Anandan R: Protective effect of dietary supplementation on mitochondrial function in liver of aged rats. Prostaglandins Leukot Essent Fatty Acids. 2007 Jun;76(6):349-55. Epub 2007 Jun 15. The dietary supplementation of 2% significantly minimized aging associated alterations in mitochondrial energy status by maintaining the activities of TCA cycle enzymes (isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase and malate dehydrogenase) and respiratory marker enzymes (NADH dehydrogenase and cytochrome-c-oxidase) at higher level in the liver mitochondria of aged rats compared with unsupplemented controls. |
1(0,0,0,1) | Details |
| 16143346 | Senthilnathan P, Padmavathi R, Magesh V, Sakthisekaran D: Modulation of TCA cycle enzymes and electron transport chain systems in experimental lung cancer. Life Sci. 2006 Jan 25;78(9):1010-4. Epub 2005 Sep 6. Decreased activities of TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) in lung cancer bearing animals were observed. |
1(0,0,0,1) | Details |
| 14604472 | Arathi G, Sachdanandam P: Therapeutic effect of Semecarpus anacardium Linn. nut milk extract on carbohydrate metabolizing and mitochondrial TCA cycle and respiratory chain enzymes in mammary carcinoma rats. J Pharm Pharmacol. 2003 Sep;55(9):1283-90. The activities of mitochondrial enzymes isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, NADH-dehydrogenase and cytochrome C oxidase were significantly lowered in mammary carcinoma-bearing rats when compared with control rats. |
1(0,0,0,1) | Details |
| 15919137 | Savitha S, Sivarajan K, Haripriya D, Kokilavani V, Panneerselvam C: Efficacy of levo and in ameliorating the decline in mitochondrial enzymes during aging. Clin Nutr. 2005 Oct;24(5):794-800. METHODS: In the present study we have evaluated the efficacy of a mitochondrial metabolite and a potent antioxidant on the activities of the tri carboxylic acid (TCA) cycle enzymes like succinate dehydrogenase, malate dehydrogenase, alpha-ketoglutarate dehydrogenase, Isocitrate dehydrogenase and electron transport complex I-IV in young and aged heart mitochondria. |
1(0,0,0,1) | Details |
| 15852400 | Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE: Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurol. 2005 May;57(5):695-703. Significant (p < 0.01) decreases occurred in the activities of the pyruvate dehydrogenase complex (-41%), isocitrate dehydrogenase (-27%), and the alpha-ketoglutarate dehydrogenase complex (-57%). |
1(0,0,0,1) | Details |
| 19715758 | Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF: Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochim Biophys Acta. 2010 Jan;1802(1):122-34. Epub 2009 Aug 26. Many experiments in tissues from humans support the notion that oxidative modification of the alpha-ketoglutarate dehydrogenase complex (KGDHC) compromises neuronal energy metabolism and enhances ROS production in Alzheimer's Disease (AD). |
1(0,0,0,1) | Details |
| 17349985 | Arulkumaran S, Ramprasath VR, Shanthi P, Sachdanandam P: Alteration of DMBA-induced oxidative stress by additive action of a modified indigenous preparation--Kalpaamruthaa. Chem Biol Interact. 2007 Apr 25;167(2):99-106. Epub 2007 Feb 4. DMBA-treated rats also showed decline in the activities of mitochondrial enzymes such as succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate dehydrogenase and isocitrate dehydrogenase. |
1(0,0,0,1) | Details |
| 12548764 | Xin M, Zhou P: [Effect of temperature on the activity of some enzymes representative of EMP pathway and TCA cycle in psychrophilic yeast]. Wei Sheng Wu Xue Bao. 2000 Oct;40(5):518-22. Alpha-ketoglutarate dehydrogenase existed possibly in isoenzyme which had different temperature characteristics. |
1(0,0,0,1) | Details |
| 16232477 | Arikawa Y, Kobayashi M, Kodaira R, Shimosaka M, Muratsubaki H, Enomoto K, Okazaki M: Isolation of sake yeast strains possessing various levels of - and/or -producing abilities by gene disruption or mutation. J Biosci Bioeng. 1999;87(3):333-9. The reductase gene (OSM1) disruptant produced sake containing a 1.5-fold higher concentration of as compared to the wild-type, whereas the alpha-ketoglutarate dehydrogenase gene (KGD1) and fumarase gene (FUMI) disruptants gave lower concentrations. |
1(0,0,0,1) | Details |
| 12742074 | Schousboe A, Sonnewald U, Waagepetersen HS: Differential roles of in GABAergic and glutamatergic neurons. . Neurochem Int. 2003 Sep-Oct;43(4-5):311-5. Thus, a metabolic scheme is proposed, according to which catabolism is coupled to the TCA cycle where the shunt replaces the alpha-ketoglutarate dehydrogenase/ synthetase reactions. |
1(0,0,0,1) | Details |
| 15965072 | Huang HM, Ou HC, Chen HL, Hou RC, Jeng KC: Protective effect of on BV-2 microglia under hypoxia or oxidative stress. Ann N Y Acad Sci. 2005 May;1042:272-8. The alpha-ketoglutarate dehydrogenase complex (KGDHC) is a mitochondrial enzyme in the TCA cycle. |
1(0,0,0,1) | Details |
| 19526285 | Mallajosyula JK, Chinta SJ, Rajagopalan S, Nicholls DG, Andersen JK: Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. Neurotox Res. 2009 Oct;16(3):186-93. Epub 2009 Mar 5. We previously demonstrated that spare respiratory capacity of the TCA cycle enzyme alpha-ketoglutarate dehydrogenase (KGDH) was completely abolished upon increasing levels of MAO-B activity in a dopaminergic cell model system (Kumar et al., J Biol Chem 278:46432-46439, 2003). |
1(0,0,0,1) | Details |
| 16906525 | Mailloux RJ, Hamel R, Appanna VD: Aluminum toxicity elicits a dysfunctional TCA cycle and accumulation in hepatocytes. J Biochem Mol Toxicol. 2006;20(4):198-208. BN-PAGE, SDS-PAGE, and Western blot analyses revealed a marked decrease in activity and expression of succinate dehydrogenase (SDH), alpha-ketoglutarate dehydrogenase (KGDH), isocitrate dehydrogenase-NAD+ (IDH), fumarase (FUM), aconitase (ACN), and cytochrome c oxidase (Cyt C Ox). 13C-NMR and HPLC studies further confirmed the disparate metabolism operative in control and Al-stressed cells and provided evidence for the accumulation of in the latter cultures. |
1(0,0,0,1) | Details |
| 17668068 | Mailloux RJ, Beriault R, Lemire J, Singh R, Chenier DR, Hamel RD, Appanna VD: The tricarboxylic acid cycle, an ancient metabolic network with a novel twist. PLoS One. 2007 Aug 1;2(1):e690. Activities of alpha-ketoglutarate dehydrogenase (KGDH), NAD-dependent isocitrate dehydrogenase (NAD-ICDH), and succinate dehydrogenase (SDH) were sharply diminished in the cellular systems exposed to conditions conducive to oxidative stress. |
1(0,0,0,1) | Details |
| 16310273 | Li M, Ho PY, Yao S, Shimizu K: Effect of lpdA gene knockout on the metabolism in Escherichia coli based on enzyme activities, intracellular metabolite concentrations and metabolic flux analysis by 13C-labeling experiments. J Biotechnol. 2006 Mar 23;122(2):254-66. Epub 2005 Nov 23. The dehydrogenase (LPD) encoded by lpdA gene is a component of the pyruvate dehydrogenase complex (PDHc), alpha-ketoglutarate dehydrogenase (AKGDH) and the cleavage multi-enzyme (GCV) systems. |
1(0,0,0,1) | Details |
| 15337301 | Bubber P, Ke ZJ, Gibson GE: Tricarboxylic acid cycle enzymes following thiamine deficiency. . Neurochem Int. 2004 Dec;45(7):1021-8. Non--dependent enzymes such as succinate dehydrogenase (SDH), thiokinase (STH) and malate dehydrogenase (MDH) were altered as much or more than -dependent enzymes such as the alpha-ketoglutarate dehydrogenase complex (KGDHC) (-21.5%) and PDHC (-10.5%). |
1(0,0,0,1) | Details |
| 20199583 | Kamaraj S, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T: attenuates mitochondrial dysfunction during benzo (a) pyrene-induced lung carcinogenesis in mice. Fundam Clin Pharmacol. 2010 Feb 22. B (a) P (50 mg/kg body weight)-induced mitochondrial abnormalities was evident from alterations in mitochondrial lipid peroxides, antioxidant status (superoxide dismutase, catalase, peroxidase, glutathione reductase, glutathione-S-transferase, and major tricarboxylic acid (TCA) cycle enzyme activities (isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, alpha-ketoglutarate dehydrogenase), electron transport chain (ETC) complexes activities and levels. |
1(0,0,0,1) | Details |
| 16786185 | Gnanapragasam A, Yogeeta S, Subhashini R, Ebenezar KK, Sathish V, Devaki T: Adriamycin induced myocardial failure in rats: protective role of Centella asiatica. Mol Cell Biochem. 2007 Jan;294(1-2):55-63. Epub 2006 Jun 20. Adriamycin (2.5 mg/kg body wt., i.p.) induced mitochondrial damage in rats was assessed in terms of decreased activities (p <0.05) of cardiac marker enzymes (lactate dehydrogenase, phosphokinase, amino transferases), TCA cycle enzymes (isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate dehydrogenase, respiratory marker enzymes (NADH-dehydrogenase, cytochrome-C-oxidase), mitochondrial antioxidant enzymes (GPx, GSH, SOD,CAT) and increased (p <0.05) level of lipid peroxidation. |
1(0,0,0,1) | Details |
| 16232421 | Arikawa Y, Kuroyanagi T, Shimosaka M, Muratsubaki H, Enomoto K, Kodaira R, Okazaki M: Effect of gene disruptions of the TCA cycle on production of in Saccharomyces cerevisiae. J Biosci Bioeng. 1999;87(1):28-36. When cultured in YPD medium containing 15% under aerobic conditions, the KGD1 (alpha-ketoglutarate dehydrogenase) gene disrupted mutant produced a lower level of than the wild-type strain, while the SDH1 (succinate dehydrogenase) gene-disrupted mutant produced an increased level of |
1(0,0,0,1) | Details |
| 15798370 | de Grey AD: Reactive species production in the mitochondrial matrix: implications for the mechanism of mitochondrial mutation accumulation. Rejuvenation Res. 2005 Spring;8(1):13-7. MtDNA mutations probably shift the intramitochondrial NAD (+)/ redox couple towards and this is now shown in vitro to cause ROS production by alpha-ketoglutarate dehydrogenase, an essential enzyme of the TCA cycle. |
1(0,0,0,1) | Details |
| 17316901 | Morland C, Henjum S, Iversen EG, Skrede KK, Hassel B: Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain. Neurochem Int. 2007 Apr;50(5):703-9. Epub 2007 Jan 20. In contrast, formation of from [U-(14) C] in awake rats (which reflects the passage of (14) C through the whole TCA cycle) and activities of pyruvate dehydrogenase, citrate synthase, alpha-ketoglutarate dehydrogenase, and fumarase in white structures were 10-23% of cortical values, optic nerve showing the lowest values. |
1(0,0,0,1) | Details |
| 12668482 | Cortassa S, Aon MA, Marban E, Winslow RL, O'Rourke B: An integrated model of cardiac mitochondrial energy metabolism and dynamics. Biophys J. 2003 Apr;84(4):2734-55. In addition, mitochondrial matrix Ca (2+), determined by Ca (2+) uniporter and Na (+)/Ca (2+) exchanger activities, regulates activity of the TCA cycle enzymes isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase. |
1(0,0,0,1) | Details |
| 18569708 | Rajendran P, Ekambaram G, Sakthisekaran D: Effect of mangiferin on benzo (a) pyrene induced lung carcinogenesis in experimental Swiss albino mice. Nat Prod Res. 2008 May 20;22(8):672-80. Decreased activities of electron transport chain complexes and TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH), in lung cancer bearing animals were observed. |
1(0,0,0,1) | Details |
| 16206171 | Waagepetersen HS, Hansen GH, Fenger K, Lindsay JG, Gibson G, Schousboe A: Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of alpha-ketoglutarate dehydrogenase. Glia. 2006 Jan 15;53(2):225-31. |
3(0,0,0,3) | Details |