Protein Information

Name HERG
Synonyms HERG; Voltage gated potassium channel; ERG; ERG1; Eag homolog; Eag related protein 1; Ether a go go related gene potassium channel 1; Ether a go go related protein 1…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
18458880 Scherer D, von Lowenstern K, Zitron E, Scholz EP, Bloehs R, Kathofer S, Thomas D, Bauer A, Katus HA, Karle CA, Kiesecker C: Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):73-83. Epub 2008 May 6.


HERG channels were expressed in the Xenopus oocyte expression system and in human embryonic kidney (HEK) cells and currents were measured with two-microelectrode voltage-clamp and whole-cell patch-clamp, respectively.
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20210726 Alvarez PA, Pahissa J: QT alterations in psychopharmacology: proven candidates and suspects. Curr Drug Saf. 2010 Jan;5(1):97-104.


Blockage of Human ether-a-go-go-related gene (HERG) potassium channel by psychoactive drugs appears to be related to this adverse effect.
1(0,0,0,1) Details
19814705 Alvarez PA, Pahissa J: QT Alterations in Psychopharmacology: Proven Candidates and Suspects. Curr Drug Saf. 2009 Oct 7.


Blockage of Human ether-a-go-go-related gene (HERG) potassium channel by psychoactive drugs appears to be related to this adverse effect.
1(0,0,0,1) Details