Protein Information

Name protein kinase C (protein family or complex)
Synonyms Protein kinase C; PKC

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
12128246 Morishita S, Aoki S: Effects of tricyclic antidepressants on protein kinase C activity in rabbit and human platelets in vivo. J Affect Disord. 2002 Aug;70(3):329-32.

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16648297 Patterson S, Flatt PR, Brennan L, Newsholme P, McClenaghan NH: Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion. J Endocrinol. 2006 May;189(2):301-10.


Insulin secretion induced by activation of adenylate cyclase and protein kinase C pathways with forskolin and phorbol 12-myristate 13-acetate were also inhibited by homocysteine.
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15955598 Pakaski M, Bjelik A, Hugyecz M, Kasa P, Janka Z, Kalman J: Imipramine and citalopram facilitate amyloid precursor protein secretion in vitro. Neurochem Int. 2005 Aug;47(3):190-5.


In this study, Western blotting was used to test the ability of the tricyclic antidepressant (TCA) imipramine or the selective serotonin reuptake inhibitor (SSRI) citalopram to change the release of APP and the protein kinase C (PKC) content.
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18429118 Carter N: Assays of protein kinases using exogenous substrates. . Curr Protoc Protein Sci. 2001 May;Chapter 13:Unit13.7.


This unit describes assays for a variety of protein kinases that require different conditions to detect and measure their activities--cyclic nucleotide-dependent kinases, protein kinase C and isoforms, casein kinases, Ca (2+)/calmodulin-dependent kinases, and tyrosine kinase.
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17395152 Srisawang P, Chatsudthipong A, Chatsudthipong V: Modulation of succinate transport in Hep G2 cell line by PKC. Biochim Biophys Acta. 2007 Jun;1768(6):1378-88. Epub 2007 Mar 1.


Short period activation of protein kinase C (PKC) by phorbol 12-myristate, 13-acetate (PMA) and alpha-adrenergic receptor agonist, phenylephrine (PE), downregulated sodium-dependent succinate transport presumably via hNaDC-3.
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12177171 Huang W, Ishii I, Zhang WY, Sonobe M, Kruth HS: PMA activation of macrophages alters macrophage metabolism of aggregated LDL. J Lipid Res. 2002 Aug;43(8):1275-82.


Degradation was mediated by protein kinase C, shown by the finding that degradation was inhibited by the protein kinase C inhibitor Go6976.
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19563063 Li X, Liao QP: [Expression of connexin 43 in ovarian cancer and its relationship with chemoresistance]. Zhonghua Fu Chan Ke Za Zhi. 2009 Jan;44(1):50-5.


OBJECTIVE: To examine the expression of protein kinase C (PKC), connexin 43 (Cx43) and non-phosphorylated Cx43 in ovarian cancer, and discuss the role of phosphorylated of Cx43 in chemoresistance in ovarian cancer.
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