| 12128246 |
Morishita S, Aoki S: Effects of tricyclic antidepressants on protein kinase C activity in rabbit and human platelets in vivo. J Affect Disord. 2002 Aug;70(3):329-32.
BACKGROUND: The purpose of this study was to examine the effects of tricyclic antidepressants (TCA) on protein kinase C (PKC) in vivo. METHODS: PKC activity in rabbit and human platelets in vivo was measured after administration of TCA and in controls. RESULTS: Administration of TCA increased PKC activity in rabbit and human platelets in vivo. CONCLUSIONS: It has been reported that activation of PKC mediates inhibition of neurotransmitter uptake and down-regulation of beta-adrenergic receptor. We suppose that TCA-induced activation of PKC may be associated, at least in part, with the mechanism of TCA. LIMITATIONS: Other signal transduction systems, such as those of protein kinase A, protein kinase G, and cyclic-AMP, also affect neurotransmitter uptake and/or down-regulation. In this study, the relationship between the TCA-PKC system and other signal transduction systems was not investigated. |
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