Protein Information

Name cytochrome P450 arachidonic acid epoxygenases
Synonyms Arachidonic acid epoxygenase; CPJ 2; CPJ2; CYP2J2; CYPIIJ 2; CYPIIJ2; Cytochrome P450 2J2; Cytochrome P450 arachidonic acid epoxygenase…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
19448409 Jiang JG, Shen GF, Chen C, Fu XN, Wang DW: Effects of cytochrome P450 arachidonic acid epoxygenases on the proliferation of tumor cells. Ai Zheng. 2009 Jan;28(1):14-9. Epub 2009 Jan 5.

METHODS: The effects of recombinant adeno-associated virus (rAAV) mediated cytochrome P450 2J2 (CYP2J2), cytochrome P450 F87V (CYPF87V) and anti-CYP2J2 on proliferation of Tca-8113, A549, Ncl-H446 and HepG2 cells were measured using MTT and flow cytometry.
51(0,1,4,6) Details
19289568 Chen C, Li G, Liao W, Wu J, Liu L, Ma D, Zhou J, Elbekai RH, Edin ML, Zeldin DC, Wang DW: Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo. J Pharmacol Exp Ther. 2009 Jun;329(3):908-18. Epub 2009 Mar 16.

In Tca-8113 cells, the CYP2J2 inhibitors decreased EET production by approximately 60%, whereas they had no effect on CYP2J2 mRNA or protein expression.
5(0,0,0,5) Details