| Name | SDHC |
|---|---|
| Synonyms | CYB560; CYBL; Cytochrome B large subunit of complex II; Integral membrane protein C2 3; Integral membrane protein CII 3; Integral membrane protein CII 3b; PGL 3; PGL3… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19200357 | Cimini D, Patil KR, Schiraldi C, Nielsen J: Global transcriptional response of Saccharomyces cerevisiae to the deletion of SDH3. BMC Syst Biol. 2009 Feb 6;3:17. |
2(0,0,0,2) | Details |
| 12231007 | Ackrell BA: Cytopathies involving mitochondrial complex II. Mol Aspects Med. 2002 Oct;23(5):369-84. Enzyme depletion and mutations in SDHA compromise TCA activity and energy production, whereas mutations in SDHB, SDHC, and SDHD induce paraganglioma. |
2(0,0,0,2) | Details |
| 19778456 | Huang KT, Dobrovic A, Fox SB: No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer. BMC Res Notes. 2009 Sep 25;2:194. Since HIF-1alpha is frequently expressed in breast carcinomas, DNA methylation at the promoter regions of the SDHA, SDHB, SDHC and SDHD and FH genes was evaluated as a possible mechanism in silencing of SDH and FH expression in breast carcinomas. |
1(0,0,0,1) | Details |
| 15795514 | Favier J, Briere JJ, Strompf L, Amar L, Filali M, Jeunemaitre X, Rustin P, Gimenez-Roqueplo AP: Hereditary paraganglioma/pheochromocytoma and inherited succinate dehydrogenase deficiency. Horm Res. 2005;63(4):171-9. Epub 2005 Mar 24. Mutations in the genes encoding the three other succinate dehydrogenase subunits (SDHB, SDHC and SDHD) have been identified in patients affected by familial or 'apparently sporadic' paraganglioma and/or pheochromocytoma, an autosomal inherited cancer-susceptibility syndrome. |
1(0,0,0,1) | Details |
| 18519664 | Cervera AM, Apostolova N, Crespo FL, Mata M, McCreath KJ: Cells silenced for SDHB expression display characteristic features of the tumor phenotype. Cancer Res. 2008 Jun 1;68(11):4058-67. In particular, mutations in the nuclear-encoded subunits of succinate dehydrogenase (SDHB, SDHC, and SDHD) cause paragangliomas and pheochromocytomas. |
1(0,0,0,1) | Details |