| Name | glycolytic enzyme |
|---|---|
| Synonyms | Brain form hexokinase; HK1; Glycolytic enzyme; HK I; HK1 sa; HK1 sb; HK1 ta; HK1 tb… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15981298 | Okumura N, Hashida-Okumura A, Kita K, Matsubae M, Matsubara T, Takao T, Nagai K: Proteomic analysis of slow- and fast-twitch skeletal muscles. . Proteomics. 2005 Jul;5(11):2896-906. A comparison between rat soleus and extensol digitorum longus (EDL) muscles that are predominantly slow- and fast-twitch fibers, respectively, showed that the EDL muscle had higher levels of glycogen phosphorylase, most glycolytic enzymes, dehydrogenase, and kinase; while the soleus muscle had higher levels of myoglobin, TCA cycle enzymes, electron transfer flavoprotein, and carbonic anhydrase III. |
1(0,0,0,1) | Details |
| 17045964 | Lee JH, Im YJ, Bae J, Kim D, Kim MK, Kang GB, Lee DS, Eom SH: Crystal structure of Thermus caldophilus phosphoglycerate kinase in the open conformation. Biochem Biophys Res Commun. 2006 Dec 1;350(4):1044-9. Epub 2006 Oct 6. Phosphoglycerate kinase (PGK) is a key glycolytic enzyme that catalyzes the reversible transfer of a from to ADP to form and ATP in the presence of Here we present the 1.8A crystal structure of unliganded PGK from Thermus caldophilus (Tca). |
1(0,0,0,1) | Details |
| 16517402 | Simon MC: Coming up for air: HIF-1 and mitochondrial consumption. Cell Metab. 2006 Mar;3(3):150-1. Hypoxic cells induce glycolytic enzymes; this HIF-1-mediated metabolic adaptation increases flux to and produces glycolytic |
1(0,0,0,1) | Details |
| 12655459 | Peng L, Shimizu K: Global metabolic regulation analysis for Escherichia coli K12 based on protein expression by 2-dimensional electrophoresis and enzyme activity measurement. Appl Microbiol Biotechnol. 2003 Apr;61(2):163-78. Epub 2003 Jan 9. The results show that, compared with the control experiment with as a carbon source under aerobic conditions, glycolytic enzymes were slightly up-regulated (<2-fold), TCA cycle enzymes were significantly down-regulated (2- to 10-fold), and fermentative enzymes such as pfl and adhE were highly up-regulated (> 10-fold) under microaerobic conditions in medium. |
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| 12125093 | Bacurau RF, O'Toole CE, Newsholme P, Costa Rosa LF: Sub-lethal concentrations of activated complement increase rat lymphocyte utilization and oxidation while lethal concentrations cause death by a mechanism involving ATP depletion. Cell Biochem Funct. 2002 Sep;20(3):183-90. We have measured the maximum activity of hexokinase, citrate synthase, glucose 6-phosphate dehydrogenase and glutaminase in rat mesenteric lymphocytes exposed to sub-lethal concentrations of activated complement (present in zymosan-activated serum, ZAS). |
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| 19949104 | Kojima H, Kobayashi A, Sakurai D, Kanno Y, Hase H, Takahashi R, Totsuka Y, Semenza GL, Sitkovsky MV, Kobata T: Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow. J Immunol. 2010 Jan 1;184(1):154-63. Epub 2009 Nov 30. The expression of genes encoding the transporters and the key glycolytic enzyme, 6-phosphofructo-2-kinase/-2,6-bishosphatase 3, was greatly reduced in HIF-1alpha-deficient cells. |
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| 15971613 | Zhang HM, Yao SJ, Peng LF, Shimizu K: [Preliminary proteome analysis for Saccharomyces cerevisiae under different culturing conditions]. Sheng Wu Gong Cheng Xue Bao. 2004 May;20(3):398-402. The expression of several glycolytic enzymes (glk, pgi, pgk, eno, pyk) was up-regulated while the expression of enzymes in oxidative pentose phosphate pathway (zwf, gnd) was down-regulated when and lactic acid were taken as carbon source. |
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| 17391017 | De Palma S, Ripamonti M, Vigano A, Moriggi M, Capitanio D, Samaja M, Milano G, Cerretelli P, Wait R, Gelfi C: Metabolic modulation induced by chronic hypoxia in rats using a comparative proteomic analysis of skeletal muscle tissue. J Proteome Res. 2007 May;6(5):1974-84. Epub 2007 Mar 29. The results indicated that proteins involved in the TCA cycle, production, and electron transport are down-regulated, whereas glycolytic enzymes and deaminases involved in and production were up-regulated. |
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| 15188415 | Voigt B, Schweder T, Becher D, Ehrenreich A, Gottschalk G, Feesche J, Maurer KH, Hecker M: A proteomic view of cell physiology of Bacillus licheniformis. Proteomics. 2004 May;4(5):1465-90. In cells grown in the presence of a significant increase of the amount of some glycolytic enzymes (TpiA, GapA, Pgk, Pgm, Eno, Pyk) and of the pyruvate dehydrogenase (PdhA-D) was found. |
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| 19804861 | Sawada K, Taki A, Yamakawa T, Seki M: Key role for transketolase activity in production by Trichosporonoides megachiliensis SN-G42. J Biosci Bioeng. 2009 Nov;108(5):385-90. Epub 2009 Jul 29. As a result, the various enzyme activities of this organism are revealed in the pentose phosphate pathway, i.e., those of hexokinase, glucose-6-phosphate dehydrogenase, dehydrogenase, transketolase, transaldolase, and reductase. |
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| 15274121 | Schmid GM, Converset V, Walter N, Sennitt MV, Leung KY, Byers H, Ward M, Hochstrasser DF, Cawthorne MA, Sanchez JC: Effect of high-fat diet on the expression of proteins in muscle, adipose tissues, and liver of C57BL/6 mice. Proteomics. 2004 Aug;4(8):2270-82. A key glycolytic enzyme was found to be downregulated in adipose tissues and muscle, suggesting that at elevated plasma fatty acid concentrations, fatty acids compete with as an oxidative fuel source. |
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| 16428761 | Tchawa Yimga M, Leatham MP, Allen JH, Laux DC, Conway T, Cohen PS: Role of gluconeogenesis and the tricarboxylic acid cycle in the virulence of Salmonella enterica serovar Typhimurium in BALB/c mice. Infect Immun. 2006 Feb;74(2):1130-40. In Salmonella enterica serovar Typhimurium, the Cra protein (catabolite repressor/activator) regulates utilization of gluconeogenic carbon sources by activating transcription of genes in the gluconeogenic pathway, the bypass, the tricarboxylic acid (TCA) cycle, and electron transport and repressing genes encoding glycolytic enzymes. |
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| 18339202 | Becker J, Klopprogge C, Wittmann C: Metabolic responses to kinase deletion in producing Corynebacterium glutamicum. Microb Cell Fact. 2008 Mar 13;7:8. RESULTS: In this work, deletion of the pyk gene, encoding kinase, was carried out in the -producing strain C. glutamicum lysCfbr, expressing a feedback resistant aspartokinase, to investigate the cellular response to deletion of this central glycolytic enzyme. |
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| 17316901 | Morland C, Henjum S, Iversen EG, Skrede KK, Hassel B: Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain. Neurochem Int. 2007 Apr;50(5):703-9. Epub 2007 Jan 20. White structures had an uptake of [(3) H] 2-deoxyglucose in vivo and activities of hexokinase, glucose-6-phosphate isomerase, and lactate dehydrogenase that were 40-50% of values in parietal cortex. |
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| 15274136 | Antelmann H, Sapolsky R, Miller B, Ferrari E, Chotani G, Weyler W, Gaertner A, Hecker M: Quantitative proteome profiling during the fermentation process of pleiotropic Bacillus subtilis mutants. Proteomics. 2004 Aug;4(8):2408-24. Furthermore, depletion of caused the induction of the trichloroacetic acid (TCA) cycle enzymes and the downregulation of glycolytic enzymes. |
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| 12548764 | Xin M, Zhou P: [Effect of temperature on the activity of some enzymes representative of EMP pathway and TCA cycle in psychrophilic yeast]. Wei Sheng Wu Xue Bao. 2000 Oct;40(5):518-22. The results indicated that aldolase, succinate dehydrogenase, and hexokinase in Y18 were very thermolabile and have high activity at low temperature. |
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| 16962558 | Brandina I, Graham J, Lemaitre-Guillier C, Entelis N, Krasheninnikov I, Sweetlove L, Tarassov I, Martin RP: Enolase takes part in a macromolecular complex associated to mitochondria in yeast. Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1217-28. Epub 2006 Jul 12. In eucaryotes, glycolytic enzymes are classically regarded as being localised in the cytosol. |
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| 19340598 | Kumar V, Sahu NP, Pal AK, Kumar S, Sinha AK, Ranjan J, Baruah K: Modulation of key enzymes of glycolysis, gluconeogenesis, amino acid catabolism, and TCA cycle of the tropical freshwater fish Labeo rohita fed gelatinized and non-gelatinized starch diet. Fish Physiol Biochem. 2009 Apr 2. A 60-day experiment was conducted to study the effect of dietary gelatinized (G) and non-gelatinized (NG) starch on the key metabolic enzymes of glycolysis (hexokinase, glucokinase, kinase, and lactate dehydrogenase), gluconeogenesis (glucose-6 phosphatase and -1,6 bisphosphatase), protein metabolism amino transferase and amino transferase), and TCA cycle (malate dehydrogenase) in Labeo rohita juveniles. |
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| 15708555 | Sugiura K, Pendola FL, Eppig JJ: Oocyte control of metabolic cooperativity between oocytes and companion granulosa cells: energy metabolism. Dev Biol. 2005 Mar 1;279(1):20-30. When oocytes were microsurgically removed from cumulus cell-oocyte complexes, the isolated cumulus cells exhibited decreased expression levels of genes encoding glycolytic enzymes, glycolysis and activity of the tricarboxylic acid (TCA) cycle. |
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| 18358458 | Sugapriya D, Shanthi P, Sachdanandam P: Restoration of energy metabolism in leukemic mice treated by a siddha drug--Semecarpus anacardium Linn. nut milk extract. Chem Biol Interact. 2008 May 9;173(1):43-58. Epub 2008 Feb 15. Leukemia-bearing mice showed a significant increase in lipid peroxides, glycolytic enzymes, a decrease in gluconeogenic enzymes and significant decrease in the activities of TCA cycle and respiratory chain enzymes as compared to control animals. |
2(0,0,0,2) | Details |
| 15098932 | Malthankar GV, White BK, Bhushan A, Daniels CK, Rodnick KJ, Lai JC: Differential lowering by treatment of activities of glycolytic and tricarboxylic acid (TCA) cycle enzymes investigated in neuroblastoma and astrocytoma cells is associated with -induced cell death. Neurochem Res. 2004 Apr;29(4):709-17. In parallel with the Mn-induced, dose-dependent decrease in cell survival, treatment of these cells with 0.01 to 4.0 mM MnCl2 for 48 h also induced dose-related decreases in their activities of hexokinase, kinase, lactate dehydrogenase, citrate synthase, and malate dehydrogenase. |
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| 12841626 | Malarkodi KP, Balachandar AV, Varalakshmi P: The influence of on adriamycin induced nephrotoxicity in rats. Mol Cell Biochem. 2003 May;247(1-2):15-22. Intravenous injections of adriamycin resulted in decreased activities of the glycolytic enzymes; hexokinase, phosphoglucoisomerase, aldolase and lactate dehydrogenase in the rat renal tissue. |
2(0,0,0,2) | Details |
| 15691747 | Mashego MR, Jansen ML, Vinke JL, van Gulik WM, Heijnen JJ: Changes in the metabolome of Saccharomyces cerevisiae associated with evolution in aerobic -limited chemostats. FEMS Yeast Res. 2005 Feb;5(4-5):419-30. In addition to this the specific activities of most glycolytic enzymes also decreased by a factor 5-10 during long-term cultivation. |
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| 14604472 | Arathi G, Sachdanandam P: Therapeutic effect of Semecarpus anacardium Linn. nut milk extract on carbohydrate metabolizing and mitochondrial TCA cycle and respiratory chain enzymes in mammary carcinoma rats. J Pharm Pharmacol. 2003 Sep;55(9):1283-90. Mammary carcinoma-bearing rats showed a significant rise in glycolytic enzymes (hexokinase, phosphoglucoisomerase and aldolase) and a simultaneous fall in gluconeogenic enzymes (glucose-6-phosphatase and 1,6-diphosphatase). |
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| 12718448 | Lai JC, White BK, Buerstatte CR, Haddad GG, Novotny EJ Jr, Behar KL: Chronic hypoxia in development selectively alters the activities of key enzymes of oxidative metabolism in brain regions. Neurochem Res. 2003 Jun;28(6):933-40. In P10 hypoxic rats, hexokinase (HK) activity in hypothalamus, hippocampus, olfactory bulb, midbrain, and cerebral cortex was significantly decreased (by 15%-30%). |
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| 18593602 | Frick NT, Bystriansky JS, Ip YK, Chew SF, Ballantyne JS: Carbohydrate and amino acid metabolism in fasting and aestivating African lungfish (Protopterus dolloi). Comp Biochem Physiol A Mol Integr Physiol. 2008 Sep;151(1):85-92. Epub 2008 Jun 14. Yet glycogenolysis may be important during aestivation based on the differing responses of two flux-generating enzymes of the glycolytic pathway, hexokinase (HK) and kinase (PK). |
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| 19923890 | Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP: The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle. 2009 Dec;8(23):3984-4001. Epub 2009 Dec 5. In support of this idea, unbiased proteomic analysis and transcriptional profiling of a new model of cancer-associated fibroblasts (caveolin-1 (Cav-1) deficient stromal cells), shows the upregulation of both (1) myo-fibroblast markers and (2) glycolytic enzymes, under normoxic conditions. |
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