| PubMed |
Abstract |
RScore(About this table) |
| 19694742 |
Kwadijk-de Gijsel S, Bijl MJ, Visser LE, van Schaik RH, Hofman A, Vulto AG, van Gelder T, Ch Stricker BH: Variation in the CYP2D6 gene is associated with a lower serum sodium concentration in patients on antidepressants. Br J Clin Pharmacol. 2009 Aug;68(2):221-5.
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4(0,0,0,4) |
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| 18070221 |
Bijl MJ, Visser LE, Hofman A, Vulto AG, van Gelder T, Stricker BH, van Schaik RH: Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol. 2008 Apr;65(4):558-64. Epub 2007 Dec 7.
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * Most antidepressants are metabolized by CYP2D6. |
3(0,0,0,3) |
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| 17662092 |
Polasek TM, Miners JO: Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants. Br J Clin Pharmacol. 2008 Jan;65(1):87-97. Epub 2007 Jul 27.
METHODS: CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A/CYP3A4 activities were investigated following co- and preincubation with TCAs using human liver microsomes (HLM) and human recombinant CYP proteins (expressed in Escherichia coli) as the enzyme sources. |
2(0,0,0,2) |
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