Protein Information

Name succinic semialdehyde dehydrogenase
Synonyms ALDH5A1; Aldehyde dehydrogenase 5 family member A1; Aldehyde dehydrogenase 5A1; Mitochondrial Succinate Semialdehyde Dehydrogenase; NAD(+) dependent succinic semialdehyde dehydrogenase; SSADH; SSDH; Succinate semialdehyde dehydrogenase…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
18846220 Ludewig F, Huser A, Fromm H, Beauclair L, Bouche N: Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis. PLoS One. 2008;3(10):e3383. Epub 2008 Oct 10.

3(0,0,0,3) Details
19576596 Seo JY, Lee CH, Cho JH, Choi JH, Yoo KY, Kim DW, Park OK, Li H, Choi SY, Hwang IK, Won MH: Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes. J Neurol Sci. 2009 Oct 15;285(1-2):88-94. Epub 2009 Jul 2.


In this study, we observed the neuroprotective effects of ebselen against ischemic damage and on GABA shunt enzymes such as glutamic acid decarboxylase 67 (GAD67), GABA transaminse (GABA-T) and succinic semialdehyde dehydrogenase (SSADH) in the hippocampal CA1 region after 5 min of transient forebrain ischemia in gerbils.
2(0,0,0,2) Details
19513197 Takahashi H, Matsumura H, Kawai-Yamada M, Uchimiya H: The cell death factor, cell wall elicitor of rice blast fungus (Magnaporthe grisea) causes metabolic alterations including GABA shunt in rice cultured cells. Plant Signal Behav. 2008 Nov;3(11):945-53.


GABA is metabolized through a bypass pathway of the TCA cycle called GABA shunt, which is composed of glutamate decarboxylase (GAD), GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH).
2(0,0,0,2) Details