| Name | glutamine synthase |
|---|---|
| Synonyms | GLNS; GLUL; GS; Glutamate ammonia ligase; Glutamate ammonia ligase; Glutamine synthase; Glutamine synthetase; PIG43… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19002891 | Zhang F, Sun X, Yi X, Zhang Y: Metabolic characteristics of recombinant Chinese hamster ovary cells expressing glutamine synthetase in presence and absence of Cytotechnology. 2006 May;51(1):21-8. Epub 2006 Aug 5. |
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| 19053364 | Schiavon M, Ertani A, Nardi S: Effects of an alfalfa protein hydrolysate on the gene expression and activity of enzymes of the tricarboxylic acid (TCA) cycle and nitrogen metabolism in Zea mays L. J Agric Food Chem. 2008 Dec 24;56(24):11800-8. The activity of a number of enzymes involved in carbon (C) metabolism (malate dehydrogenase, MDH; isocitrate dehydrogenase, IDH; citrate synthase, CS) and N reduction and assimilation reductase, NR; reductase, NiR; glutamine synthetase, GS; synthase, GOGAT; aspartate aminotransferase, AspAT) was significantly induced by EM supply to plants, and the transcription pattern of MDH, IDH, CS, and NR strongly correlated with data of enzyme activity. |
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| 16857877 | Walsh PJ, Kajimura M, Mommsen TP, Wood CM: Metabolic organization and effects of feeding on enzyme activities of the dogfish shark (Squalus acanthias) rectal gland. J Exp Biol. 2006 Aug;209(Pt 15):2929-38. Several enzymes showed a large increase in activity post-feeding, including dehydrogenase in rectal gland and liver, and in rectal gland, isocitrate dehydrogenase, citrate synthase, lactate dehydrogenase, amino transferase, amino transferase, glutamine synthetase and Na (+)/K (+) ATPase. |
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| 15145544 | Hertz L: Intercellular metabolic compartmentation in the brain: past, present and future. Neurochem Int. 2004 Jul-Aug;45(2-3):285-96. This pool, which was designated 'the small compartment,' is now known to be made up predominantly or exclusively of astrocytes, which accumulate avidly and express glutamine synthetase activity, whereas this enzyme is absent from neurons, which eventually were established to constitute 'the large compartment.' During the following decades, the metabolic compartment concept was refined, aided by emerging studies of energy metabolism and uptake in cellularly homogenous preparations and by the histochemical observations that the two key enzymes glutamine synthetase and pyruvate carboxylase are active in astrocytes but absent in neurons. |
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| 15145545 | Garcia-Espinosa MA, Rodrigues TB, Sierra A, Benito M, Fonseca C, Gray HL, Bartnik BL, Garcia-Martin ML, Ballesteros P, Cerdan S: Cerebral metabolism and the cycle as detected by in vivo and in vitro 13C NMR spectroscopy. Neurochem Int. 2004 Jul-Aug;45(2-3):297-303. However, more recent experimental approaches using inhibitors of the glial tricarboxylic acid (TCA) cycle (trifluoroacetic acid, TFA) or of glutamine synthase sulfoximine, MSO) reveal that a considerable portion of the energy required to support synthesis is derived from the oxidative metabolism of in the astroglia and that a significant amount of the neurotransmitter is produced from neuronal or lactate rather than from glial |
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| 19470091 | Alvarez M, Huygens D, Olivares E, Saavedra I, Alberdi M, Valenzuela E: Ectomycorrhizal fungi enhance and nutrition of Nothofagus dombeyi under drought conditions by regulating assimilative enzyme activities. Physiol Plant. 2009 Aug;136(4):426-36. Epub 2009 Apr 4. In greenhouse experiments, shoot and root dry weights, mycorrhizal colonization, foliar N and P concentrations, and root enzyme activities synthase aminotransferase (GOGAT), EC 1.4.1.13-14), glutamine synthetase (GS, EC 6.3.1.2), dehydrogenase (GDH, EC 1.4.1.2-4), reductase (NR, EC 1.6.6.1), and acid phosphomonoesterase (PME, EC 3.1.3.1-2)] were determined as a function of soil-water content. |
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| 17346854 | Johansen ML, Bak LK, Schousboe A, Iversen P, Sorensen M, Keiding S, Vilstrup H, Gjedde A, Ott P, Waagepetersen HS: The metabolic role of in detoxification of in cultured mouse neurons and astrocytes. Neurochem Int. 2007 Jun;50(7-8):1042-51. Epub 2007 Feb 6. In addition, this will provide the alpha-ketoglutarate carbon skeleton for and synthesis by dehydrogenase and glutamine synthetase (astrocytes only), respectively, both reactions fixing ammonium. |
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| 17545289 | Li W, Lu CD: Regulation of carbon and utilization by CbrAB and NtrBC two-component systems in Pseudomonas aeruginosa. J Bacteriol. 2007 Aug;189(15):5413-20. Epub 2007 Jun 1. The Ntr systems of these ntrB mutants became constitutively active, as revealed by the activity profiles of dehydrogenase, synthase, and glutamine synthetase. |
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| 19002931 | Yallop CA, Norby PL, Jensen R, Reinbach H, Svendsen I: Characterisation of G418-induced metabolic load in recombinant CHO and BHK cells: effect on the activity and expression of central metabolic enzymes. Cytotechnology. 2003 Jul;42(2):87-99. For both CHO and BHK cells, there was an increase in the activity of glutaminase, dehydrogenase and glutamine synthetase, suggesting an increased flux through the glutaminolysis pathway. |
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| 18006192 | Maciejewski PK, Rothman DL: Proposed cycles for functional trafficking in synaptic neurotransmission. Neurochem Int. 2008 Mar-Apr;52(4-5):809-25. Epub 2007 Oct 2. To date, the - cycle has been the dominant paradigm for understanding the coordinated, compartmentalized activities of phosphate-activated glutaminase (PAG) and glutamine synthetase (GS) in support of functional trafficking in vivo. |
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