| Name | aldehyde dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | aldehyde dehydrogenase; aldehyde dehydrogenases |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12210539 | Poon R, Nakai J, Yagminas A, Benoit F, Moir D, Chu I, Valli VE: Subchronic toxicity of chloral hydrate on rats: a drinking water study. J Appl Toxicol. 2002 Jul-Aug;22(4):227-36. Liver aldehyde dehydrogenase (ALDH) was significantly depressed, whereas liver hydroxylase activity was significantly elevated in both males and females receiving the highest dose. |
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| 17258477 | Kim Y, Nandakumar MP, Marten MR: Proteome map of Aspergillus nidulans during osmoadaptation. Fungal Genet Biol. 2007 Sep;44(9):886-95. Epub 2007 Jan 26. Sequence homology and conserved domains were used to assign probable function to twenty-one proteins currently annotated as "hypothetical." In osmoadapted cells, there was an increased expression of glyceraldehyde-3-phosphate dehydrogenase and aldehyde dehydrogenase, as well as a decreased expression of enolase, suggesting an increased biosynthesis and decreased use of the TCA cycle. |
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| 17500021 | Cordier H, Mendes F, Vasconcelos I, Francois JM: A metabolic and genomic study of engineered Saccharomyces cerevisiae strains for high production. Metab Eng. 2007 Jul;9(4):364-78. Epub 2007 Apr 7. Further deletion of ADH1 and overexpression of ALD3, encoding, respectively, the major NAD+-dependent alcohol dehydrogenase and a cytosolic NAD+-dependent aldehyde dehydrogenase yielded a yeast strain able to produce 0.46 g (g -1) at a maximal rate of 3.1 mmol (g dry mass)(-1) h (-1) in aerated batch cultures. |
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| 16882532 | Bronley-DeLancey A, McMillan DC, McMillan JM, Jollow DJ, Mohr LC, Hoel DG: Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol. Environ Health Perspect. 2006 Aug;114(8):1237-42. CH is metabolized to the hepatocarcinogen trichloroacetate (TCA) by aldehyde dehydrogenase (ALDH) and to the noncarcinogenic metabolite trichloroethanol (TCOH) by alcohol dehydrogenase (ADH). |
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