Protein Information

Name IP 10
Synonyms 10 kDa interferon gamma induced protein; C7; CXCL10; Gamma IP10; IFI10; INP10; IP 10; Interferon gamma induced precursor…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
18226543 Sauder C, Pedras-Vasconcelos J, Puig M, Verthelyi D: The IP10 (CXCL10) specific cDNA probe of the mCK-5c multiprobe RNase protection assay kit carries two nucleotide insertions that complicate the interpretation of results. Cytokine. 2008 Feb;41(2):182-6. Epub 2008 Jan 15.

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17164723 Xie JF, Wang G, Debonera F, Han R, Dorf ME, Hancock W, Olthoff KM: Selective neutralization of the chemokine TCA3 reduces the increased injury of partial versus whole liver transplants induced by cold preservation. Transplantation. 2006 Dec 15;82(11):1501-9.


Quantitative analysis showed that compared with expression in whole grafts harvested after the same period of cold ischemia, partial grafts had eightfold more T-cell activation gene (TCA)-3 (CCL1) chemokine messenger RNA (mRNA) expression (P <0.01) and sixfold more inducible protein (IP)-10 chemokine (CCL10) mRNA expression (P <0.01), as well as increased expression of the chemokine receptors CCR8 (receptor for TCA3) and CXCR3 (receptor for IP-10; P <0.01).
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16274458 Renninger ML, Seymour R, Lillard JW Jr, Sundberg JP, HogenEsch H: Increased expression of chemokines in the skin of chronic proliferative dermatitis mutant mice. Exp Dermatol. 2005 Dec;14(12):906-13.


RNA isolated from the skin of mutant and littermate control mice revealed a significant increase in Ccl1 (TCA-3), Ccl2 (MCP-1), Ccl11 (eotaxin), Ccl17 (TARC), Cxcl10 (IP-10), and the chemokine receptor Ccr3.
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15145609 Mi W, Belyavskyi M, Johnson RR, Sieve AN, Storts R, Meagher MW, Welsh CJ: Alterations in chemokine expression following Theiler's virus infection and restraint stress. J Neuroimmunol. 2004 Jun;151(1-2):103-15.


Ltn, IP-10 and RANTES were elevated in both the spleen and the brain at day 7 pi, and were significantly decreased by RS in the brain.
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16488173 Klein M, Paul R, Angele B, Popp B, Pfister HW, Koedel U: Protein expression pattern in experimental pneumococcal meningitis. . Microbes Infect. 2006 Apr;8(4):974-83. Epub 2006 Jan 18.


Newly identified proteins during the acute stage of the disease (until 30 h after infection) included lymphotactin (XCL-1), MIP-1gamma (CCL9) and MCP-5 (CCL12), cytokine responsive gene- 2 (CRG-2/CXCL10) and CXCL16, and insulin-like growth factor binding protein 3 (IGFBP3).
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