| Name | complex I |
|---|---|
| Synonyms | 39kD; CI 39kD; Complex I; Complex I 39kD; NADH dehydrogenase (ubiquinone) Fe S protein 2 like; NADH ubiquinone oxidoreductase 39 kDa subunit mitochondrial; NADH ubiquinone oxidoreductase 39 kDa subunit; NDUFA 9… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15715660 | Hsu M, Srinivas B, Kumar J, Subramanian R, Andersen J: depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving implications for Parkinson's disease. J Neurochem. 2005 Mar;92(5):1091-103. An early biochemical change in the Parkinsonian substantia nigra (SN) is reduction in total (GSH + levels in affected dopaminergic neurons prior to depletion in mitochondrial complex I activity, loss, and cell death. |
4(0,0,0,4) | Details |
| 19526285 | Mallajosyula JK, Chinta SJ, Rajagopalan S, Nicholls DG, Andersen JK: Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. Neurotox Res. 2009 Oct;16(3):186-93. Epub 2009 Mar 5. MAO-B mediated increases in H (2) O (2) also appeared to result in direct oxidative inhibition of both mitochondrial complex I and aconitase. |
3(0,0,0,3) | Details |
| 17406791 | Meyer EH, Heazlewood JL, Millar AH: Mitochondrial acyl carrier proteins in Arabidopsis thaliana are predominantly soluble matrix proteins and none can be confirmed as subunits of respiratory Complex I. Plant Mol Biol. 2007 Jun;64(3):319-27. Epub 2007 Apr 4. |
3(0,0,0,3) | Details |
| 12783190 | Appanna VD, Hamel RD, Levasseur R: The metabolism of aluminum and biosynthesis of in Pseudomonas fluorescens. Curr Microbiol. 2003 Jul;47(1):32-9. Thus, it appears that after the uptake of Al- this complex is metabolized intracellularly. |
1(0,0,0,1) | Details |
| 15919137 | Savitha S, Sivarajan K, Haripriya D, Kokilavani V, Panneerselvam C: Efficacy of levo and in ameliorating the decline in mitochondrial enzymes during aging. Clin Nutr. 2005 Oct;24(5):794-800. METHODS: In the present study we have evaluated the efficacy of a mitochondrial metabolite and a potent antioxidant on the activities of the tri carboxylic acid (TCA) cycle enzymes like succinate dehydrogenase, malate dehydrogenase, alpha-ketoglutarate dehydrogenase, Isocitrate dehydrogenase and electron transport complex I-IV in young and aged heart mitochondria. |
1(0,0,0,1) | Details |
| 20353438 | Lemire J, Mailloux R, Auger C, Whalen D, Appanna VD: Pseudomonas fluorescens orchestrates a fine metabolic-balancing act to counter aluminium toxicity. Environ Microbiol. 2010 Mar 25. To compensate for the severely diminished enzymes like Complex I, Complex II and Complex IV, the upregulation of a H (2) O-generating oxidase enables the metabolism of the sole carbon source via a modified TCA cycle. |
1(0,0,0,1) | Details |
| 16885387 | Nissim I, Horyn O, Daikhin Y, Nissim I, Luhovyy B, Phillips PC, Yudkoff M: Ifosfamide-induced nephrotoxicity: mechanism and prevention. Cancer Res. 2006 Aug 1;66(15):7824-31. We hypothesized that inhibition of complex I (C-I) by chloroacetaldehyde (CAA), a metabolite of IFO, is the chief cause of nephrotoxicity, and that (AGM), which we found to augment mitochondrial oxidative phosphorylation and beta-oxidation, would prevent nephrotoxicity. |
1(0,0,0,1) | Details |
| 18615634 | Cruz JR, Becker BA, Morris KF, Larive CK: NMR characterization of the host-guest inclusion complex between beta-cyclodextrin and doxepin. Magn Reson Chem. 2008 Sep;46(9):838-45. An alternative view of the doxepin-beta-CD complex is presented in this work using analysis of complexation-induced chemical shifts (CICSs), the method of continuous variation (Job's analysis), and analysis of ROESY spectra. |
1(0,0,0,1) | Details |
| 16120273 | de Grey AD: A proposed mechanism for the lowering of mitochondrial electron leak by caloric restriction. Mitochondrion. 2001 Aug;1(2):129-39. Here it is proposed that the major metabolic shift enabling reduced production is a diversion of much of the electron flux generated by glycolysis and the TCA cycle away from its usual destination, Complex I, and to the plasma membrane redox system. |
1(0,0,0,1) | Details |
| 16765624 | Simpson NE, Han Z, Berendzen KM, Sweeney CA, Oca-Cossio JA, Constantinidis I, Stacpoole PW: Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate. Mol Genet Metab. 2006 Sep-Oct;89(1-2):97-105. Epub 2006 Jun 12. The pyruvate dehydrogenase complex (PDC) is integral to metabolism and energetics. |
1(0,0,0,1) | Details |